利用反复冷冻-解冻法和相分离法,制备出用于软骨和软骨下骨修复的纳米羟基磷灰石（nHA）/聚乙烯醇（PVA）/聚酰胺（PA66）功能梯度材料。研究表面层PVA的力学性能和摩擦学性能,及软骨下骨nHA/PA66（m（HA）∶m（PA66）=1∶1）支架的力学性能及生物学性能。结果表明PVA拉伸强度为1.938MPa,平均摩擦系数在生理盐水及代血浆润滑条件下分别为0.076和0.085;nHA/PA66复合多孔支架孔隙率为80.93%,孔径为50～500μm,压缩强度和压缩模量分别为0.88和15.21MPa,且具有良好的生物相容性。
The functionally gradient material of poly（vinyl alcohol）/ nano-hydroxyapatite/polyamide66 for repair of articular cartilage and underlying bone was prepared by freeze-thawing method and thermally induced phase inversion processing technique.The mechanical and friction property of PVA were tested.The biocompatibility and mechanical property of nHA/PA66 scaffold were also investigated.The results showed that the tensile strength of PVA was 1.94MPa,the mean of friction coefficient in physiological saline and in plasma substitute were 0.076 and 0.085,respectively.The n-HA/PA66 scaffolds exhibited high porosity（about 80.93%） and a pore size ranging from 50 to 500μm.The compressive strength and modulus of scaffolds were 0.88 MPa and 15.21MPa.Such a material exhibited good biocompatibility and high bioactivity.
参考文献
| [1] | Bodugoz-Senturk H;Macias CE;Kung JH;Muratoglu OK .Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute.[J].Biomaterials,2009(4):589-596. |
| [2] | Hutmacher DW .Scaffolds in tissue engineering bone and cartilage.[J].Biomaterials,2000(24):2529-2543. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%