微束辐照装置及其在生物和材料领域中的应用

原子核物理评论 , 2009, 26(3): 215-221.

微束辐照装置及其在生物和材料领域中的应用

盛丽娜 ^1, , 宋明涛 ^2, , 刘杰 ^3, , 孙友梅 ^4, , 党秉荣 ^5, , 李文建 ^6, , 杨晓天 ^7, , 高大庆 ^8, , 张小奇 ^9, , 何源 ^10, , 张斌 ^11, , 苏弘 ^12, , 满开第 ^13, , 郭艺珍 ^14, , 王志光 ^15, , 肖国青 ^16,

1.中国科学院近代物理研究所,甘肃,兰州,730000;中国科学院研究生院,北京,100049

2.中国科学院近代物理研究所,甘肃,兰州,730000

3.中国科学院近代物理研究所,甘肃,兰州,730000

4.中国科学院近代物理研究所,甘肃,兰州,730000

5.中国科学院近代物理研究所,甘肃,兰州,730000

6.中国科学院近代物理研究所,甘肃,兰州,730000

7.中国科学院近代物理研究所,甘肃,兰州,730000

8.中国科学院近代物理研究所,甘肃,兰州,730000

9.中国科学院近代物理研究所,甘肃,兰州,730000

10.中国科学院近代物理研究所,甘肃,兰州,730000

11.中国科学院近代物理研究所,甘肃,兰州,730000

12.中国科学院近代物理研究所,甘肃,兰州,730000

13.中国科学院近代物理研究所,甘肃,兰州,730000

14.中国科学院近代物理研究所,甘肃,兰州,730000

15.中国科学院近代物理研究所,甘肃,兰州,730000

16.中国科学院近代物理研究所,甘肃,兰州,730000

基金项目: 中国科学院重大科研装备研制项目(O713040YZ0)

关键词：微束 , 重离子 , 中高能 , 应用

Microbeam Irradiation Facilities and Their Applications in Biology and Material Field

自从20世纪50年代开始利用微束辐照生物活细胞以来,由于微束独特的辐照特征,其在生物学、材料学、生物医学、航空航天科学、环境科学、地质学、微加工等领域得到了广泛的应用.在前人大量研究的基础上,对微束装置及其应用进行总结概括.展望了微束的发展趋势并简单介绍中国科学院近代物理研究所正在兴建的中高能重离子微束辐照装置.

参考文献

[1]	Tschachotin S.Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales,1920,83:1593.
[2]	Zirkle R E,Bloom W.Science,1953,117:487.
[3]	Dymnikov A D,Ovsyannikova L P,Yavor S Y.Soviet Physics-Technical Physics(USA),1963,4:293.
[4]	Legge G J F.Nucl Instr and Meth,1997,B130:9.
[5]	Cookson J A,Pilling F D.Harwell Report AERE-R 6300,1970.
[6]	Fischer B E,Spohr R.Nucl Instr and Meth,1980,168:241.
[7]	Brenner D J,Hall E J.Radiation Protection Dosimetry,2002,99:283.
[8]	Randers-Pehrson G,Geard C,Johnson G,et al.Radiation Research,2000,153:221; Datzmann G,Dollinger G,Goeden C,et al.Radiation Research,2000,153:223; Schettino G,Folkard M,Vojnovic B,et al.Radiation Research,2000,153:223; Greif K,Brede H J.Radiation Research,2000,153:235; Dymnikov A D,Brenner D J,Johnson G,et al.Radiation Research,2000,153:236.
[9]	Randers-Pehrson G,Geard C,Johnson G,et al.Radiation Research,2000,153:221; Datzmann G,Dollinger G,Goeden C,et al.Radiation Research,2000,153:223; Schettino G,Folkard M,Vojnovic B,et al.Radiation Research,2000,153:223; Greif K,Brede H J.Radiation Research,2000,153:235; Dymnikov A D,Brenner D J,Johnson G,et al.Radiation Research,2000,153:236.
[10]	Randers-Pehrson G,Geard C,Johnson G,et al.Radiation Research,2000,153:221; Datzmann G,Dollinger G,Goeden C,et al.Radiation Research,2000,153:223; Schettino G,Folkard M,Vojnovic B,et al.Radiation Research,2000,153:223; Greif K,Brede H J.Radiation Research,2000,153:235; Dymnikov A D,Brenner D J,Johnson G,et al.Radiation Research,2000,153:236.
[11]	Randers-Pehrson G,Geard C,Johnson G,et al.Radiation Research,2000,153:221; Datzmann G,Dollinger G,Goeden C,et al.Radiation Research,2000,153:223; Schettino G,Folkard M,Vojnovic B,et al.Radiation Research,2000,153:223; Greif K,Brede H J.Radiation Research,2000,153:235; Dymnikov A D,Brenner D J,Johnson G,et al.Radiation Research,2000,153:236.
[12]	Randers-Pehrson G,Geard C,Johnson G,et al.Radiation Research,2000,153:221; Datzmann G,Dollinger G,Goeden C,et al.Radiation Research,2000,153:223; Schettino G,Folkard M,Vojnovic B,et al.Radiation Research,2000,153:223; Greif K,Brede H J.Radiation Research,2000,153:235; Dymnikov A D,Brenner D J,Johnson G,et al.Radiation Research,2000,153:236.
[13]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[14]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[15]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[16]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[17]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[18]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[19]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[20]	Folkard M,Vojnovic B,Gilchrist S,et al.Radiation Research,2002,158:366; Greif K-D,Brede H J.Radiation Research,2002,158:367; Haupmer A,Datzmann G,Dollinger G,et al.Radiation Research,2002,158:367; Schenkel T,Reijonen J,Persaud A,et al.Radiation Research,2002,158:368; Randers-Pehrson G,Johnson G W,Marino S A,et al.Radiation Research,2002,158:369; Michelet C,Moretto Ph,Barberet Ph,et al.Radiation Research,2002,158:370; Cherubini R,Conzato M,Galeazzi G,et al.Radiation Research,2002,158:371; Tanner J,Spemann D,Reinert T,et al.Radiation Research,2002,158:372.
[21]	Yanch J C,Folkert M F,Ledoux R J,etal.Radiation Research,2004,161:96; Wu Y,Hu S,Li J,et al.Radiation Research,2004,161:99; Kobayashi K,Usami N,Maezawa H,et al.Radiation Research,2004,161:101.
[22]	Yanch J C,Folkert M F,Ledoux R J,etal.Radiation Research,2004,161:96; Wu Y,Hu S,Li J,et al.Radiation Research,2004,161:99; Kobayashi K,Usami N,Maezawa H,et al.Radiation Research,2004,161:101.
[23]	Yanch J C,Folkert M F,Ledoux R J,etal.Radiation Research,2004,161:96; Wu Y,Hu S,Li J,et al.Radiation Research,2004,161:99; Kobayashi K,Usami N,Maezawa H,et al.Radiation Research,2004,161:101.
[24]	Kirkby K J,Grime G W,Webb R P,et al.Radiation Research,2006,166:654; Arteaga-Marrero N,Pallon J,Auzelyte V,et al.Radiation Research,2006,166:655; Garty G,Ross G J,Bigelow A W,et al.Radiation Research,2006,166:656.
[25]	Kirkby K J,Grime G W,Webb R P,et al.Radiation Research,2006,166:654; Arteaga-Marrero N,Pallon J,Auzelyte V,et al.Radiation Research,2006,166:655; Garty G,Ross G J,Bigelow A W,et al.Radiation Research,2006,166:656.
[26]	Kirkby K J,Grime G W,Webb R P,et al.Radiation Research,2006,166:654; Arteaga-Marrero N,Pallon J,Auzelyte V,et al.Radiation Research,2006,166:655; Garty G,Ross G J,Bigelow A W,et al.Radiation Research,2006,166:656.
[27]	Wang Xufei,Wang Xiaohua,Chen Lianyun,et al.Science Bulletin,2004,49(16):1677(in Chinese).(王旭飞.王晓华.陈连运等.科学通报,2004,49(16):1677.)
[28]	Jamieson D N.Nucl Instr and Meth,2001,B181:1.
[29]	Randers-Pehrson G,Geard C R,Johnson G,et al.Radiation Research,2001,158:210.
[30]	Fukuda M,Kurashima S,Okumura S,et al.Available from:http://epaper.kek.jp/c04/data/CYC2004_papers/21B2.pdf.
[31]	Grupen C.Available from:http://arXiv.org/PS_cache/physics/pdf/0004/0004015vl.pdf.
[32]	Folkard M,Vojnovic B,Prise K M,et al.Nucl Instr and Meth,2002,B188:49.
[33]	Folkard M,Prise K M,Grime G,et al.Applied Radiation and Isotopes,2008,doi:10.1016/j.apradiso.2008.06.015.
[34]	Belyakov O V,Malcolmson A M,Folkard M,et al.Cancer,2001,84(5):674.
[35]	Mothersill C,Seymour C.Radiation Research,2001,155:759.
[36]	Greif K D,Brede H J,Frankenberg D,et al.Nucl Instr and Meth,2004,B217:505.
[37]	Fournier C,Beaker D,Winter M,et al.Radiation Research,2007,187:194.
[38]	Kanasugi Y,Hamada N,Wada S,et al.International Journal of Radiation Biology,2007,83:73.
[39]	Bowler D A,Moore S R,Macdonald D A,et al.Mutation Research,2006,597:50.
[40]	Hamada N,Ni M,Funayama T,et al.Mutation Research,2008,639:35.
[41]	Kadhim M A.Nature,1992,355:738[DOI].
[42]	Zirkle R E.Advances in Biological and Medical Physics.New York:Academic Press,1957,103-146.
[43]	Bloom W.Reviews of Modern Physics,1959,31:66.
[44]	Setlow R B.Mutation Research,1999,430:169.
[45]	Schimmerling W.Radiation and Environmental Biophysics,1995,34:133.
[46]	Hai Lan.Super Science,2004,5:4(in Chinese).Available from:http://tech.sina.com.cn/other/2004-05-12/1155360476.shtml.(海蓝.大科技.2004,5:4.)
[47]	Cucinotta F A,Durante M.Lancet Oncology,2006,7:431.
[48]	Brown K A,Fliller R,Li Zheng,et al.Proceedings of EPAC 2002,Paris,France,554-556.Available from:http://www.pubs.bnl.gov/documents/24105.pdf.
[49]	Zhou Lihin,Li Wenjian,Qu Yin,et al.Nuclear Physics Review,2008,25(2):165(in Chinese).(周利斌,李文建,曲颖等.原子核物理评论,2008,25(2):165.)
[50]	Qu Yin,Li Wenjian,Zhou Libin,et al.Nuclear Physics Review,2007,24(4):294(in Chinese).(曲颖,李文建,周利斌等.原子核物理评论,2007,24(4):294.)
[51]	Kobayashi Y,Funayama T,Wada S,et al.Biological Sciences in Space,2004,18(4):235.
[52]	Kamiya T,Oikawa M,Ohshima T,et al.Nucl Instr and Meth,2003,B210:206.
[53]	Kamiya T,Sakai T,Hirao T,et al.Nucl Instr and Meth,2001,B181:280.
[54]	Hou Mingdong,Zhen Honglou,Zhang Qingxiang,et al.Nuclear Physics Review,2000,17 (3):165(in Chinese).(侯明东,甄红楼,张庆祥等.原子核物理评论,2000,17(3):165.)
[55]	Metzger S,Fischer B E.Microelectronic Engineering,1996,31:41.
[56]	Sakai T,Oikawa M,Sato T.Journal of Nuclear and Radiochemical Sciences,2005,6(1):69.
[57]	Matsuyama S,Ishii K,Yamazaki H,et al.Nuel Instr and Meth,2007,B260:55.
[58]	IBA Techniques.Available from:http://www.irb.hr/en/str / zef / z3labs/ liis/ metode/.
[59]	WattF,KanJA,RajtaI,et al.Nucl Instr and Meth,2003,B210:14.
[60]	Kan J A,Sanchez J L,Xu B,et al.Nucl Instr and Meth,1999,B148:1085.
[61]	Kan J A,Bettiol A A,Watt F.Applied Physics Letters,2003,83(8):1629.
[62]	Fischer B E.Nuel Instr and Meth,1988,B30:284.
[63]	Miyawaki N,Kurashima S,Okumura S,et al.Available from:http://epaper.kek.jp/c04/data/CYC2004 _ papers/18P28.pdf.
[64]	Song Mingtao,Sheng Lina,Wang Zhiduang,et al.Chinese Physics C (HEP & NP),2008,82 (Sup.Ⅰ):259 (in Chinese).(宋明涛,盛丽娜,王志光等.中国物理C,2008,32(增刊Ⅰ):259.)

上一张下一张

计量

下载量()
访问量()

作者相关

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网