将不同形态AZ31B镁合金植入实验动物（兔子）体内，并以钛合金作对照组，研究镁合金对实验动物的影响及其在实验动物体内的降解情况。研究结果表明，镁合金植入2周后，植入物周围有骨痂生成，8周时生成成熟的骨组织。镁合金植入并未对机体的循环、免疫、泌尿系统产生影响，体内降解产物主要为钙镁磷灰石，可经肾脏代谢，血液中的镁离子浓度在正常值范围内波动。本文实验研究提示，镁合金植入动物体内早期阶段是安全的，且有诱导机体新骨生成的作用。
In order to study the effect of magnesium alloy on the animals, the AZ31B magnesium alloys with different dimensions were implantated in the New-Zealand rabbits, with a titanium alloy（Ti-6Al-4V) as a control. It was found from the experiments that the osteotylus was found surround the magnesium alloy after 2 weeks implantation, and it turned into ripe bone tissue at 8 weeks. The implantation of the magnesium alloy did not influence the recirculating, immune and urinary systems of the rabbit. The magnesium calcium apatite, which was the main degradation product of the magnesium alloy, could be metabolismed by the kidney. The magnesium ions concentration in blood was in the range of normal values. It can be concluded that it is safe for the rabbit in the early stage of the magnesium alloy implantation, and the implant can be beneficial to the new bone formation.
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| [3] | |
| [4] | |
| [5] | |
| [6] |
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