目的：研究多孔磷酸钙骨组织工程支架的表面微纳米化改性。方法通过双氧水发泡法制备多孔磷酸钙骨组织工程支架,利用水热法对材料进行微纳米化表面改性。通过扫描电镜观察材料的显微结构,通过 X 射线衍射仪分析测试材料改性层相成分。结果材料改性处理后,孔隙率为(63±8)%,大孔孔径为(310±30)μm。材料表面及内孔壁生成羟基磷灰石微纳米晶粒或晶须,晶须长20~40μm,直径为100~300 nm。结论多孔磷酸钙陶瓷材料的内外表面经水热法处理微纳米化表面改性后,材料性能得到提升。
Objective To research the surface micro/ nano-modification of porous calcium phosphate bone tissue engineering scaffolds. Methods Porous calcium phosphate bone tissue engineering scaffolds were prepared by the H2 O2 foaming method. Then the hydrothermal method was applied for the surface micro/ nano-modification. The scanning electron microscopy (SEM) was used for microstructure observations, and the X-ray diffraction (XRD) was used to analyze the phase composition of the modified layer. Results After the surface modification, scaffolds with a total porosity of (63±8)% , and a pore size of (310±30) μm were ob-tained. The modified surface layers were hydroxyapatite nanocrystals or whiskers, the length of whisker ranged 20 ~ 40 μm, and the diameter was in range of 100 ~ 300 nm. Conclusion The inner and outer surfaces of porous calcium phosphate scaffolds formed a micro/ nano-modification layer by hydrothermal treatment. The performance of the material was improved.
参考文献
| [1] | 黄占杰 . 磷酸钙陶瓷生物降解研究的进展[J].功能材料,1997,28(1):1-4. HUANG Zhan-jie. Development of Biodegradable Calcium Phosphate Ceramics [J]. Functional Materials, 1997, 28(1):1-4.,1997. |
| [2] | VEIS A . Materials Science-A Window on Biomineraliza-tion[J].Science,2005,307(5714):1419-1420.,2005. |
| [3] | YU X,CAI S,XU G . Low Temperature Fabrication of High Strength Porous Calcium Phosphate and the Evaluation of the Osteoconductivity[J].Journal of Materials Science-Ma-terials in Medicine,2009,20(10):2025-2034.,2009. |
| [4] | WANG K,ZHOU C,HONG Y. A Review of Protein Adsorp-tion on Bioceramics [J]. Interface Focus, 2012, 2(3):259-277.,2012. |
| [5] | HENCH L L,POLAK J M . Third-generation Biomedical Ma-terials[J].Science,2002,295(5557):1014-1017.,2002. |
| [6] | KARAGEORGIOU V,KAPLAN D . Porosity of 3D Biomate-rial Scaffolds and Osteogenesis[J].Biomaterials,2005,26(27):5474-5491.,2005. |
| [7] | WILSON C E,DE BRUIJN J D,VANBLITTERSWIJK C A . Design and Fabrication of Standardized Hydroxyapatite Scaf-folds with a Defined Macro-architecture by Rapid Prototy-ping for Bone-tissue-engineering Research[J].Journal of Biomedical Materials Research Part A,2004,68(1):123-132.,2004. |
| [8] | OLIVEIRA J F,SOARES G A . Effect of Process Parameters on the Characteristics of Porous Calcium Phosphate Cera-mics for Bone Tissue Scaffolds[J].Artif Organs,2003,27(5):406-411.,2003. |
| [9] | HOLLISTER S J . Porous Scaffold Design for Tissue Engi-neering[J].Nature Materials,2005,4(7):518-524.,2005. |
| [10] | FANG L M,GAO P,LENG Y . High Strength and Bioactive Hydroxyapatite Nano-particles Reinforced Ultrahigh Molecu-lar Weighttpolyethylene[J].Composites:Part B,2007,38 |
| [11] | 蔡开勇.纳米生物材料及其界面特性对成骨细胞生长影响的研究进展[J].材料导报,2007(02):109-111,124. |
| [12] | WEBSTER T J,SCHADLER L S,SIEGEL R W,et al . En-hanced Osteoblast-like Cell Functions on Nanophase Cera-mics[J].Biomaterials,2001,22(11):1327-1335.,2001. |
| [13] | LIU C,HAN Z,CZERNUSZKA J T. Gradient Collagen/Na-nohydroxyapatite Composite Scaffold:Development and Characterization[J]. Acta Biomater, 2009, 5(2):661-669.,2009. |
| [14] | 王泽华,王长浩,周泽华,江少群.高温反应合成金属-陶瓷复合涂层技术的研究现状[J].表面技术,2012(03):115-119. |
| [15] | 黄朝,吴宇,夏海滨,王贻宁,王爱华.微波诱导羟基磷灰石/钛合金界面反应的研究[J].表面技术,2013(01):53-55,74. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%