利用化学共沉积法在改性葡聚糖体系下制备了以超顺磁性纳米氧化铁为核心, 外包葡聚糖的壳核结构复合粒子. 对制备过程控制因素进行了详细的研究, 实验结果表明: 利用改性葡聚糖为表面活性剂, 碱源快速滴加, 合理的控制反应时间, 温度可形成小核的超顺磁性纳米氧化铁-葡聚糖复合纳米粒子.在优化的实验条件下, 得到核心的平均粒径5nm, 总体的平均粒径为7.8nm, 并利用XRD、TEM和GLS等手段对其结构, 形态和粒径分布进行了表征.
Compound nano-particles of the superparamagnetic iron oxide, which are core-shell structure with iron oxide as core and dextran as shell, were prepared in the single-carboxyl
dextran water-base solution by a chemical co-deposition method. The factors of controlling the processing were investigated systematically. The compound particle’s
morphology and microstructure and the distribution of particale diameters were investigated by means of XRD, TEM and GLS. The resultes show
that the diameter of the compound nano particle can be decreased by accurately controlling the modification dextran quantity added, the drip-speed of
NH4OH and the reaction time as well as reaction temperature. Under the conditions of optimum parameters, the core-shell compound structure particle average
diameter is 7.8nm, the average core diameter of iron oxide is 5nm and the thick of dextran shell is 1～1.5nm.
参考文献
| [1] | Gellisse J, Axmann C, Prescher A, et al. Msgn. Reson. Imaging., 1999, 17: 557-567. [2] Mandeville J B, Moore J,Chesler D A. Magn. Reson. Med., 1997, 37: 885-889. [3] 张密林, 王君, 辛艳凤, 等. 应用科技, 2000, 27 (6): 20-21. [4] 邱广亮, 粟淑媛, 金志兰, 等. 精细化工, 1999, 16: 38-40. [5] 李民勤, 徐慧显, 何炳林. 高等学校化学学报, 1996, 12 (6): 744-746. [6] Weissleder R, Papisov M I. Reviews of Magnetic Resonance in Medicine, 1992, 4: 1-20. [7] 肖进新, 赵振国. 表面活性剂应用原理. 北京: 化学工业出版社, 2003. 483-484. [8] 陈雷, 杨文军, 黄程, 等. 高分子材料科学与工程. 1998, (4): 53-54. [9] 张立德, 牟季美. 纳米材料和纳米结构. 北京: 科学出版社, 2001. 99-100. [10] 黄俊, 官建国, 袁润章. 复合材料学报, 1999, (4): 17-19. [11] 朱屯, 王福明, 王习东. 国外纳米材料技术进展与应用, 北京: 化学工业出版社, 2002. 198. |
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