通过调控嵌段共聚物的嵌段组成可实现水-油两亲,并可在水相中形成的稳定的胶束,从而为难溶性药物的负载提供了可能.该研究合成一种新型的两嵌段的聚丙烯酸异丁酯-b-聚甲基丙烯酸吗啉乙酯共聚物PMAQ-b-PMEMA.并对两亲性嵌段共聚物PMAQ-b-PMEMA胶束的物理性能和对紫杉醇的负载能力进行了研究.研究结果表明,PMAQ-b-PMEMA胶束稳定性良好,负载紫杉醇能力较强,是一种优良的难溶药物载体.
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