优良的骨修复材料可以缩短骨愈合周期,降低不愈合的发生率.锶离子被发现具有促进骨形成的作用,将锶元素掺入骨粉材料将可能制作出一种有前景的骨修复材料.在研究中锶元素被尝试通过离子交换的方法掺入骨粉材料,实验观察了锶元素掺入骨质中的能力.新材料的细胞毒性通过MTT方法进行评价.原代培养的成骨细胞被用来评价新材料的生物相容性.结果发现锶元素在骨粉中的掺入比例可以高达10％,新材料没有细胞毒性,与普通骨粉相比成骨细胞的相对增殖率达到后者的129％,ALP活性则达到后者的132％.因此,通过离子交换方法可以制备性能优异的掺锶同种骨粉移植材料.
参考文献
| [1] | Bakker,A.D.;Zandieh-Doulabi,B.;Klein-Nulend,J. .Strontium Ranelate affects signaling from mechanically-stimulated osteocytes towards osteoclasts and osteoblasts[J].Bone,2013(1):112-119. |
| [2] | Guo D;Xu K;Han Y .The in situ synthesis of biphasic calcium phosphate scaffolds with controllable compositions, structures, and adjustable properties.[J].Journal of biomedical materials research, Part A,2009(1):43-52. |
| [3] | Cazalbou S;Combes C;Eichert D;Rey C;Glimcher MJ .Poorly crystalline apatites: evolution and maturation in vitro and in vivo.[J].Journal of bone and mineral metabolism,2004(4):310-317. |
| [4] | Bala,Y.;Farlay,D.;Boivin,G. .Bone mineralization: From tissue to crystal in normal and pathological contexts[J].Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,2013(8):2153-2166. |
| [5] | Roschger P;Manjubala I;Zoeger N;Meirer F;Simon R;Li C;Fratzl Zelman N;Misof BM;Paschalis EP;Streli C;Fratzl P;Klaushofer K .Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment.[J].Journal of bone and mineral research,2010(4):891-900. |
| [6] | Qiu K;Zhao XJ;Wan CX;Zhao CS;Chen YW .Effect of strontium ions on the growth of ROS17/2.8 cells on porous calcium polyphosphate scaffolds[J].Biomaterials,2006(8):1277-1286. |
| [7] | Li Y;Li Q;Zhu S;Luo E;Li J;Feng G;Liao Y;Hu J .The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats.[J].Biomaterials,2010(34):9006-9014. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%