欢迎登录材料期刊网

材料期刊网

高级检索

本文通过对甲壳素脱乙酰制得壳聚糖,并利用“冷冻爆破法”制备了壳聚糖溶液,在该溶液体系中采用环氧丙烷作为醚化剂,在碱催化下与壳聚糖进行反应,成功地在均相反应体系中制备了羟丙基壳聚糖.利用核磁共振氢谱(1 H-NMR)和傅里叶变换红外光谱(FT-IR)表征了产物的结构,并利用紫外可见分光光度计(UV-vis)测试了羟丙基壳聚糖的温敏性能.结果表明,壳聚糖脱乙酰度为75%左右,制备得到的羟丙基壳聚糖取代度(DS)为2.47,具有可逆的温度响应性.

参考文献

[1] Klouda L;Mikos AG .Thermoresponsive hydrogels in biomedical applications.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(1):34-45.
[2] Hua Wei;Si-Xue Cheng;Xian-Zheng Zhang .Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers[J].Progress in Polymer Science,2009(9):893-910.
[3] Ruixue Liu;Michael Fraylich;Brian R. Saunders .Thermoresponsive copolymers: from fundamental studies to applications[J].Colloid and polymer science,2009(6):627-643.
[4] L. Andrew Lyon;Zhiyong Meng;Neetu Singh .Thermoresponsive microgel-based materials[J].Chemical Society Reviews,2009(4):865-874.
[5] 林荣珍,苗晶,董声雄.壳聚糖硫酸酯pH敏感性水凝胶的制备及其性能[J].材料科学与工程学报,2008(06):950-953,957.
[6] Aseyev,V;H.Tenhu;F.Winnik.Non-ionic Thermoresponsive Polymers in Water[A].Springer,Berlin,Heidelberg,2011:29-89.
[7] Bhattarai N;Ramay HR;Gunn J;Matsen FA;Zhang MQ .PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(3):609-624.
[8] 张其荣,王征科,胡巧玲.乙醇对壳聚糖基骨修复支架形貌和性能的影响[J].材料科学与工程学报,2012(05):724-727.
[9] 施云峰,谢德明,周长忍.壳聚糖与丙交酯接枝共聚物的制备与表征[J].材料科学与工程学报,2008(01):114-117,124.
[10] 李浩,王征科,胡巧玲.N-琥珀酰壳聚糖的制备及其性能[J].材料科学与工程学报,2011(04):541-546.
[11] Kim S;Nishimoto SK;Bumgardner JD;Haggard WO;Gaber MW;Yang Y .A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer.[J].Biomaterials,2010(14):4157-4166.
[12] Cho,J;M.-C.Heuzey .Dynamic scaling for gelation of a thermosensitive chitosan-β-glycerophosphate hydrogel[J].Colloid and Polymer Science,2007,286(04):427-434.
[13] Cavallaro, G.;Lazzara, G.;Milioto, S. .Aqueous phase/nanoparticles interface: Hydroxypropyl cellulose adsorption and desorption triggered by temperature and inorganic salts[J].Soft matter,2012(13):3627-3633.
[14] Guido S. .PHASE BEHAVIOR OF AQUEOUS SOLUTIONS OF HYDROXYPROPYLCELLULOSE[J].Macromolecules,1995(13):4530-4539.
[15] Lu XH.;Hu ZB.;Schwartz J. .Phase transition behavior of hydroxypropylcellulose under interpolymer complexation with poly(acrylic acid)[J].Macromolecules,2002(24):9164-9168.
[16] Shunsuke YUJI;Sadahito UTO .Selective Reflection of Hydroxypropyl Cellulose Prepared with Autoclave[J].Japanese journal of applied physics,2006(4a):2833-2834.
[17] Shi RW.;Burt HM. .Synthesis and characterization of amphiphilic hydroxypropylcellulose-graft-poly(epsilon-caprolactone)[J].Journal of Applied Polymer Science,2003(3):718-727.
[18] Jun Gao;George Haidar;Xihua Lu;Zhibing Hu .Self-Association of Hydroxypropylcellulose in Water[J].Macromolecules,2001(7):2242-2247.
[19] Susana CM Fernandes;Carmen SR Freire;Armando JD Silvestre .Novel materials based on chitosan and cellulose[J].Polymer international,2011(6):875-882.
[20] Wan Y.;Creber KAM.;Peppley B.;Bui VT. .Ionic conductivity and tensile properties of hydroxyethyl and hydroxypropyl chitosan membranes[J].Journal of Polymer Science, Part B. Polymer Physics,2004(8):1379-1397.
[21] IN KYU PARK;YOUNG HWAN PARK .Preparation and Structural Characterization of Water-Soluble O-Hydroxypropyl Chitin Derivatives[J].Journal of Applied Polymer Science,2001(13):2624-2632.
[22] Yu Liu;Gang Chen;Ke-Ao Hu .Synthesis, characterization and structural analysis of polylactide grafted onto water-soluble hydroxypropyl chitin as backbone[J].Journal of Materials Science Letters,2003(19):1303-1305.
[23] Belgacem MN.;Gandini A.;Blayo A. .SURFACE CHARACTERIZATION OF POLYSACCHARIDES, LIGNINS, PRINTING INK PIGMENTS, AND INK FILLERS BY INVERSE GAS CHROMATOGRAPHY[J].Journal of Colloid and Interface Science,1996(2):431-436.
[24] Min Fan;Qiaoling Hu;Kai Shen .Preparation and structure of chitosan soluble in wide pH range[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2009(1):66-71.
[25] Mohammad R. Kasaai .Determination of the degree of N-acetylation for chitin and chitosan by various NMR spectroscopy techniques: A review[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2010(4):801-810.
[26] Lavertu M;Xia Z;Serreqi AN;Berrada M;Rodrigues A;Wang D;Buschmann MD;Gupta A .A validated 1H NMR method for the determination of the degree of deacetylation of chitosan.[J].Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis,2003(6):1149-1158.
[27] Gulay Bayramoglu;K. Can Akcah;Sinan Gultekin .Preparation and Characterization of Poly(hydroxyethyl methacrylate-co-poly(ethyl- eneglycol-methacrylate)/Hydroxypropyl-chitosan) Hydrogel Films: Adhesion of Rat Mesenchymal Stem Cells[J].Macromolecular Research,2011(4):385-395.
[28] Shigemasa Y.;Sashiwa H.;Saimoto H.;Matsuura H. .EVALUATION OF DIFFERENT ABSORBANCE RATIOS FROM INFRARED SPECTROSCOPY FOR ANALYZING THE DEGREE OF DEACETYLATION IN CHITIN[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,1996(3):237-242.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%