欢迎登录材料期刊网

材料期刊网

高级检索

利用溶液共混法以及冷冻干燥法制备了多孔碳纤维/聚乳酸/壳聚糖(CF/PLA/CS)三元复合生物材料,通过扫描电子显微镜(SEM)观察了其表面形貌特征,并对其细胞相容性进行了评价.实验结果表明,利用上述复合方法制备的三维多孔材料的孔径为20~500μm,孔分布均匀,孔与孔之间相互连通;碳纤维的分散、冷冻干燥温度对材料结构影响较大,随冷冻温度的降低,支架的孔隙变小、变规则,内部结构趋向均一,孔隙率有所降低;该材料与细胞具有较好的相容性,符合组织支架材料的基本要求.

参考文献

[1] 徐梁,熊成东.聚乳酸/硅灰石生物医用复合材料的降解性能[J].重庆工学院学报(自然科学版),2009(03):69-75.
[2] Kim K;Yu M;Zong X;Chiu J;Fang D;Seo YS;Hsiao BS;Chu B;Hadjiargyrou M .Control of degradation rate and hydrophilicity in electrospun non-woven poly(D,L-lactide) nanofiber scaffolds for biomedical applications.[J].Biomaterials,2003(27):4977-4985.
[3] Borden M;El Amin SF;Attawia M;Laurencin CT .Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair.[J].Biomaterials,2003(4):597-609.
[4] Hiroshi Hatta .Strength improvement by densification of C/C composites[J].Carbon: An International Journal Sponsored by the American Carbon Society,2001(1):82-90.
[5] 沈烈,乔飞,张稚燕.碳纤维增强羟基磷灰石/聚乳酸复合生物材料的制备和力学性能[J].实验力学,2007(03):385-389.
[6] 熊信柏,李贺军,黄剑锋,马威,郑勇,郭领军.一种制备仿生生物活性钙磷涂层的新方法[J].稀有金属材料与工程,2004(03):313-316.
[7] Williams JM;Adewunmi A;Schek RM;Flanagan CL;Krebsbach PH;Feinberg SE;Hollister SJ;Das S .Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering[J].Biomaterials,2005(23):4817-4827.
[8] Taboas JM;Maddox RD;Krebsbach PH;Hollister SJ .Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds.[J].Biomaterials,2003(1):181-194.
[9] Ho MH;Kuo PY;Hsieh HJ;Hsien TY;Hou LT;Lai JY;Wang da M .Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methods.[J].Biomaterials,2004(1):129-138.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%