探索了影响氯化亚锡还原法制备碳纳米管和不同粒径纳米碳黑的99mTc标记化合物的多种因素,在给定实验条件下,99mTc的标记率能够稳定达到90%以上. 细胞培养液中标记物的放射化学纯度在2.5 h中保持在(86±4)%范围内. 制备的标记化合物满足碳纳米颗粒细胞摄取率测定和细胞毒性机制研究的实验要求. 实验结果提示,99mTc标记过程是基于还原得到的低价Tc在碳纳米颗粒表面上的物理吸附机理.
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