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综述了用聚乳酸类可生物降解型高分子材料制备缓控释药物载体的研究现状.分别介绍了该类材料在微粒给药载体、凝胶制剂、缓释支架和埋植制剂的应用及其制备方法.阐述了目前聚乳酸类生物降解材料在缓控释药物制剂中的主要问题,展望了其发展前景.

参考文献

[1] Dai M;Xu X;Song J;Fu S;Gou M;Luo F;Qian Z .Preparation of camptothecin-loaded PCEC microspheres for the treatment of colorectal peritoneal carcinomatosis and tumor growth in mice.[J].Cancer letters,2011(2):189-196.
[2] Liu KL;Widjaja E;Huang Y;Ng XW;Loo SC;Boey FY;Venkatraman SS .A new insight for an old system: protein-PEG colocalization in relation to protein release from PCL/PEG blends.[J].Molecular pharmaceutics,2011(6):2173-2182.
[3] Kriegel, C.;Amiji, M. .Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2011(1):77-86.
[4] Kiran R. Chaudhari;Neha Shah;Hetal Patel .Preparation of porous PLGA microspheres with thermoreversible gel to modulate drug release profile of water-soluble drug: Bleomycin sulphate[J].Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres,2010(4):303-313.
[5] Panusa A;Selmin F;Rossoni G;Carini M;Cilurzo F;Aldini G .Methylprednisolone-loaded PLGA microspheres: a new formulation for sustained release via intra-articular administration. A comparison study with methylprednisolone acetate in rats.[J].Journal of Pharmaceutical Sciences,2011(11):4580-4586.
[6] Koppolu B;Rahimi M;Nattama S et al.Development of multiple-layer polymeric particles for targeted and controlled drug delivery[J].Nanomedicine,2010,6(02):355.
[7] Kuo, C.-F.;Tsao, N.;Chou, H.-H.;Liu, Y.-L.;Hsieh, W.-C. .Release of FITC-BSA from poly(L-lactic acid) microspheres analysis using flow cytometry[J].Colloids and Surfaces, B. Biointerfaces,2012(1):271-276.
[8] Selvam P;El Sherbiny IM;Smyth HD .Swellable hydrogel particles for controlled release pulmonary administration using propellant-driven metered dose inhalers.[J].Journal of aerosol medicine and pulmonary drug delivery,2011(1):25-34.
[9] Yeo Y;Park K .Control of encapsulation efficiency and initial burst in polymeric microparticle systems.[J].Archives of pharmacal research,2004(1):1-12.
[10] Doan TV;Couet W;Olivier JC .Formulation and in vitro characterization of inhalable rifampicin-loaded PLGA microspheres for sustained lung delivery.[J].International Journal of Pharmaceutics,2011(1/2):112-117.
[11] Thomas C;Rawat A;Hope Weeks L;Ahsan F .Aerosolized PLA and PLGA nanoparticles enhance humoral, mucosal and cytokine responses to hepatitis B vaccine.[J].Molecular pharmaceutics,2011(2):405-415.
[12] Kim H;Lee J;Kim TH;Lee ES;Oh KT;Lee DH;Park ES;Bae YH;Lee KC;Youn YS .Albumin-coated porous hollow poly(lactic-co-glycolic acid) microparticles bound with palmityl-acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes.[J].Pharmaceutical research,2011(8):2008-2019.
[13] Oh, Y.J.;Lee, J.;Seo, J.Y.;Rhim, T.;Kim, S.-H.;Yoon, H.J.;Lee, K.Y. .Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2011(1):56-62.
[14] Kim H;Park H;Lee J;Kim TH;Lee ES;Oh KT;Lee KC;Youn YS .Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes.[J].Biomaterials,2011(6):1685-1693.
[15] Lee, J.;Oh, Y.J.;Lee, S.K.;Lee, K.Y. .Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(1):61-67.
[16] Jelvehgari M;Valizadeh H;Rezapour M;Nokhodchi A .Control of encapsulation efficiency in polymeric microparticle system of tolmetin.[J].Pharmaceutical development and technology,2010(1):71-79.
[17] Seju U;Kumar A;Sawant KK .Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies.[J].Acta biomaterialia,2011(12):4169-4176.
[18] Hamishehkar H;Emami J;Najafabadi AR;Gilani K;Minaiyan M;Mahdavi H;Nokhodchi A .Effect of carrier morphology and surface characteristics on the development of respirable PLGA microcapsules for sustained-release pulmonary delivery of insulin.[J].International Journal of Pharmaceutics,2010(1/2):74-85.
[19] Hamed Hamishehkar;Jaber Emami;Abdolhossien Rouholamini Najafabadi .Influence of carrier particle size, carrier ratio and addition of fine ternary particles on the dry powder inhalation performance of insulin-loaded PLGA microcapsules[J].Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems,2010(3):289-295.
[20] Hamishehkar H;Emami J;Najafabadi AR;Gilani K;Minaiyan M;Hassanzadeh K;Mahdavi H;Koohsoltani M;Nokhodchi A .Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats.[J].Biopharmaceutics and Drug Disposition,2010(2/3):189-201.
[21] 姜栋,赵伟霞,赛龙,王青山.聚乳酸防粘连凝胶在鼻窦镜手术后的应用[J].中医临床研究,2010(07):112-113.
[22] 侯振伟,白鹤翔,张风华,安雁鸣,杜晓燕.布洛芬缓释凝胶的制备[J].中国组织工程研究与临床康复,2009(25):4865-4867.
[23] Gao Y;Ren F;Ding B;Sun N;Liu X;Ding X;Gao S .A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel.[J].Journal of drug targeting,2011(7):516-527.
[24] Saffer EM;Tew GN;Bhatia SR .Poly(lactic acid)-poly(ethylene oxide) block copolymers: new directions in self-assembly and biomedical applications.[J].Current medicinal chemistry,2011(36):5676-5686.
[25] Hollinger J O .Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA)[J].Journal of Biomedical Materials Research,1983,17(01):71.
[26] Ravelingien M;Mullens S;Luyten J;D'Hondt M;Boonen J;De Spiegeleer B;Coenye T;Vervaet C;Remon JP .Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2010(3):366-370.
[27] Chen J;Luo Y;Hong L et al.Synthesis,characterization and osteoconductivity properties of bone fillers based on alendronate-loaded poly(ε-caprolactone)/hydroxyapatite microspheres[J].Journal of Materials Science:Materials in Medicine,2011,22(03):547.
[28] Son, J.S.;Appleford, M.;Ong, J.L.;Wenke, J.C.;Kim, J.M.;Choi, S.H.;Oh, D.S. .Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2011(2):133-140.
[29] 刘章起,李春亮.药物洗脱支架:较强安全性和良好近远期效果之评价[J].中国组织工程研究与临床康复,2010(29):5451-5454.
[30] Theodore Parker;Vipul Davé;Robert Falotico;Jonathon Zhao;Thai Nguyen;Sylvia He;Yi-Ping Sun;Campbell Rogers .Control of cilostazol release kinetics and direction from a stent using a reservoir-based design.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2012(3):603-610.
[31] Soon-Joong Kim;Jae-Geun Park;Jung Ho Kim;Jung Sun Heo;Jeong-Woo Choi;Yang-Soo Jang;Junghan Yoon;Seung Jin Lee;Keun Kwon .Development of a Biodegradable Sirolimus-Eluting Stent Coated by Ultrasonic Atomizing Spray[J].Journal of nanoscience and nanotechnology,2011(7):5689-5697.
[32] Kotsar,A.;Nieminen,R.;Isotalo,T.;Mikkonen,J.;Uurto,I.;Kellom?ki,M.;Talja,M.;Moilanen,E.;Tammela,T.L.J. .Preclinical evaluation of new indomethacin-eluting biodegradable urethral stent[J].Journal of endourology,2012(4):387-392.
[33] Heo D N;Lee J B;Bae M S et al.Development of nanofiber coated indomethacin duting stent for tracheal regeneration[J].J Nanosci Nanotechn,2011,11(07):5711.
[34] Kim M;Jung B;Park JH .Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin.[J].Biomaterials,2012(2):668-678.
[35] 杨寒,程亮,郭圣荣.5-氟尿嘧啶聚己内酯针状植入剂的研究[J].中国药学杂志,2009(08):602-606.
[36] Kempe, S.;M?der, K. .In situ forming implants - An attractive formulation principle for parenteral depot formulations[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2012(2):668-679.
[37] Camargo J A;Sapin A;Nouvel C et al.Injectable PLAbased in situ forming implants for controlled release of Ivermectin a BCS class Ⅱ drug:Solvent selection based on physico-chemical characterization[J].Drug Development and Industrial Pharmacy,2012,39(01):1.
[38] Shen,J.;Burgess,D.J. .Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings[J].International Journal of Pharmaceutics,2012(1/2):341-348.
[39] Ju,Y.M.;Yu,B.;West,L.;Moussy,Y.;Moussy,F. .A dexamethasone-loaded PLGA microspheres/collagen scaffold composite for implantable glucose sensors[J].Journal of biomedical materials research, Part A,2010(1):200-210.
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