热作用可以提高肿瘤血管对脂质体药物的通透性,从而促进肿瘤内部的药物传输.本文建立了一个新的模型对热促进脂质体药物在肿瘤内输送的治疗方式进行了数值研究.模型将肿瘤划分为血管丰富的周边区域和无血管的中心区域.数值计算结果显示热作用能有效促进肿瘤内脂质体药物的传输.
参考文献
| [1] | Szoka F C.Liposomal Drug Delivery:Current Status and Future Prospects[J].Membrane Fusion,1991:845-890. |
| [2] | Kong,G;Braun,RD;Dewhirst,MW .Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.[J].Cancer research,2000(16):4440-4445. |
| [3] | Ning S;Macleod K;Hahn G M et al.Hyperthermia Induces Dox Release from Long-Circulating Liposomes and Enhances Their Anti-Tumor Efficacy[J].International Journal of Radiation Oncology,Biology,Physics,1994,29(04):827-834. |
| [4] | Ward JP.;King JR. .Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures[J].Mathematical Biosciences: An International Journal,2003(2):177-207. |
| [5] | El-Kareh A W;Secomb T W et al.A Mathematical Model for Cisplatin Cellular Pharmacodynamics[J].Neoplasia,2003,5(02):161-169. |
| [6] | El Kareh AW;Secomb TW .A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance.[J].Neoplasia: an international journal for oncology research,2004(2):117-127. |
| [7] | El-Kareh A W;Secomb T W et al.A Mathematical Model for Comparison of Bolus Injection,Continuous Infusion,and Liposomal Delivery of Doxorubicin to Tumor Cells[J].Neoplasia,2000,2(04):325-338. |
| [8] | Lankelma J;Femandez Luque R;Pinedo M et al.Simulation Model of Dox Activity in Islets of Human Breast Cancer Cells[J].Microvascular Research,2000,59(01):149-161. |
| [9] | Liu P;Zhang A;Xu Y;Xu LX .Study of non-uniform nanoparticle liposome extravasation in tumour.[J].International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,2005(3):259-270. |
| [10] | Nugent L J;R K Jain .Extravascular Diffusion in Normal and Neoplastic Tissues[J].CANCER RESEARCH,1984,44(01):238-244. |
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