水热腐蚀对羟基磷灰石形貌及生物活性的影响

人工晶体学报, 2016, 45(2): 441-446.

水热腐蚀对羟基磷灰石形貌及生物活性的影响

刘毅 ^1, , 张彪 ^2, , 张利锋 ^3, , 郑鹏 ^4, , 原晓艳 ^5,

1.陕西科技大学材料科学与工程学院,西安,710021

2.陕西科技大学材料科学与工程学院,西安,710021

3.陕西科技大学材料科学与工程学院,西安,710021

4.陕西科技大学材料科学与工程学院,西安,710021

5.陕西科技大学材料科学与工程学院,西安,710021

基金项目: 陕西省教育厅专项科研计划(2013JK0936) 教育部高等学校博士学科点专项科研基金新教师类资助项目(20136125120003) 陕西科技大学博士科研启动基金(BJ11-26,BJ12-10)

关键词：羟基磷灰石 , 水热腐蚀 , 表面形貌 , 模拟体液 , 生物活性

Effect of Hydrothermal Etching Processes on Morphology and Bioactivity of Hydroxyapatite

Keywords： hydroxapatite , hydrothermal etching , surface morphology , simulated body fluid , bioactivity

以透明羟基磷灰石(HAp)陶瓷为原材料,采用水热工艺对其表面进行腐蚀处理,然后将HAp浸泡在模拟体液(SBF)中进行体外生物活性评价,研究了水热腐蚀温度对HAp表面形貌及生物活性的影响.利用扫描电镜(SEM)、透射电镜(TEM)、X射线衍射仪(XRD)、X射线能谱仪(EDS)和激光扫描共聚焦显微镜(LSCM)等对样品进行表征.结果表明:随水热腐蚀温度的提高,HAp表面呈现先疏松后致密的结构变化,而生物活性先升高后逐渐降低,这与HAp暴露晶面的界面能差异有关.160℃水热腐蚀10 h后HAp表面疏松多孔,表现出更加优越的体外生物活性.

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