α-Oxopentanedioic acid isonicotinoyl hydrazone (H2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, 1H NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H2O)2]Cl2·H2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity (R1) of the Gd-complex was determined by INVREC Au program.
参考文献
| [1] | Takahashi M .New frontiers of diagnostic radiology[J].Journal of Radioanalytical and Nuclear Chemistry,1999,239(01):37. |
| [2] | Cacheris W P;Quay S C;Rocklage S M .The relationship between thermodynamics and the toxicity of Gadolinium complexes[J].Magnetic Resonance Imaging,1990,8:467. |
| [3] | YANG Zhengyin,LI Fashen,YANG Li,YANG Rudong.Synthesis and relaxivity of polycarboxylic hydrazone rare earth complexes--Relaxivity of a -oxo-pentanedioic acid benzoyl hydrazone Gd-complexes[J].科学通报（英文版）,2000(20):1844-1850. |
| [4] | 杨正银,杨汝栋,蔡利平.α-酮戊二酸-2、4-二硝基苯腙稀土配合物的合成与表征[J].应用化学,2000(04):371-374. |
| [5] | Yang Z Y;Yang R D .Synthesis and relaxivity of α-oxo-γ-ethoxycarbonyl-butanoic acid thiosemicarbazone rare earth complexes[J].Synthesis and Reactivity in Inorganic and Metal-organic Chemistry,2002,32(06):1061. |
| [6] | Yang Z Y;Yang R D;Li Q .Synthesis, characterization and biological activity of rare earth complexes of 1-Phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl-ketone isonicotinoyl hydrazone[J].Synthesis and Reactivity in Inorganic and Metal-organic Chemistry,1999,29(02):205. |
| [7] | Chen Y Z.Organic Analysis[M].北京:高等教育出版社,1983:587. |
| [8] | Sinha S P .Spectroscopic investigations of some neodymium complexes[J].Spectrochimica Acta,1966,22:57. |
| [9] | Lauffer R B .Paramagnetic metal complexes as water proton relaxation agents for NMR imaging theory design[J].Chemical Reviews,1987,87:901. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%