欢迎登录材料期刊网

材料期刊网

高级检索

纳米羟基磷灰石因其具有良好的生物相容性和生物活性,被广泛应用于骨组织的修复与替代材料.但由于磷灰石本身力学性能较差限制了其应用范围,因此,提高及制备综合性能优越的纳米羟基磷灰石/聚合物复合生物材料是当今研究的热门领域.本文综述了近年来n-HA/聚合物复合材料的国内外研究进展情况,并对此类材料存在的问题进行了分析,探讨了n-HA骨修复材料的发展方向.

参考文献

[1] 王迎军,杜昶,赵娜如,叶建东,陈晓峰.仿生人工骨修复材料研究[J].华南理工大学学报(自然科学版),2012(10):51-58.
[2] 胡堃,刘斌.骨移植材料发展趋势[J].生物骨科材料与临床研究,2010(03):32-38.
[3] Bhatt,R.A.;Rozental,T.D. .Bone Graft Substitutes[J].Hand clinics,2012(4):457-468.
[4] 廖世波,赖琛,张志雄,盛立远,奚廷斐.骨修复复合材料及其相关问题的研究进展[J].中国生物医学工程学报,2012(05):755-761.
[5] L A Mills;A H R W Simpson .In vivo models of bone repair.[J].The Journal of Bone and Joint Surgery. British VolumecBritish Orthopaedic Association , Australian Orthopaedic Association , Canadian Orthopaedic Association . . . [et al],2012(7):865-874.
[6] Kolk,A.;Handschel,J.;Drescher,W.;Rothamel,D.;Kloss,F.;Blessmann,M.;Heiland,M.;Wolff,K.-D.;Smeets,R. .Current trends and future perspectives of bone substitute materials - From space holders to innovative biomaterials[J].Journal of Cranio-Maxillofacial Surgery,2012(8):706-718.
[7] Heo SJ;Kim SE;Wei J;Hyun YT;Yun HS;Kim DH;Shin JW;Shin JW .Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process.[J].Journal of biomedical materials research, Part A,2009(1):108-116.
[8] 郑曙阳,李高宏.共滴定法制备羟基磷灰石/魔芋葡甘聚糖复合材料[J].硅酸盐通报,2011(01):162-166,171.
[9] Tsai SW;Hsu FY;Chen PL .Beads of collagen-nanohydroxyapatite composites prepared by a biomimetic process and the effects of their surface texture on cellular behavior in MG63 osteoblast-like cells.[J].Acta biomaterialia,2008(5):1332-1341.
[10] Fukui N;Sato T;Kuboki Y;Aoki H .Bone tissue reaction of nano-hydroxyapatite/collagen composite at the early stage of implantation.[J].Bio-medical materials and engineering,2008(1):25-33.
[11] Zhou J;Xu C;Wu G;Cao X;Zhang L;Zhai Z;Zheng Z;Chen X;Wang Y .In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen-hydroxyapatite layered scaffolds.[J].Acta biomaterialia,2011(11):3999-4006.
[12] 张利,李玉宝,魏杰,左奕,韩纪梅,吴兰,王学江.纳米羟基磷灰石/壳聚糖复合骨修复材料的共沉淀法制备及其性能表征[J].功能材料,2005(03):441-444.
[13] Hu Q;Li B;Wang M;Shen J .Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture.[J].Biomaterials,2004(5):779-785.
[14] 李湘南,陈晓明,彭志明,李世普.纳米羟基磷灰石/壳聚糖载药微球的制备及性能[J].中南大学学报(自然科学版),2011(05):1232-1237.
[15] 张华亮,王文良,关静,刘英杰,初殿伟,张西正.双层壳聚糖/羟基磷灰石复合支架的制备及性能研究[J].医疗卫生装备,2008(09):4-6,11.
[16] 李保强,胡巧玲,钱秀珍,方征平,沈家骢.原位沉析法制备可吸收壳聚糖/羟基磷灰石棒材[J].高分子学报,2002(06):828-833.
[17] 胡晓兰,谢鹏辉,王雯皓,余荣禄,申丙星,董炎明.原位增强羟基磷灰石/壳聚糖复合棒材[J].复合材料学报,2011(02):123-129.
[18] 仇满德,王晓燕,李旭,刘红梅,姚子华.纳米羟基磷灰石/壳聚糖-海藻酸钠复合材料的制备及微分析[J].材料导报,2013(04):60-62.
[19] Marc Bohner .Resorbable biomaterials as bone graft substitutes[J].Materials Today,2010(1/2):24-30.
[20] Wang, X.H.;Shi, S.;Guo, G.;Fu, S.Z.;Fan, M.;Luo, F.;Zhao, X.;Wei, Y.Q.;Qian, Z.Y. .Preparation and characterization of a porous scaffold based on poly(D,L-lactide) and N-hydroxyapatite by phase separation[J].Journal of biomaterials science,2011(14):1917-1929.
[21] Tongxin Wang;Laurence C. Chow;Stanislav A. Frukhtbeyn;Andy Hai Ting;Quanxiao Dong;Mingshu Yang;James W. Mitchell .Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent[J].Journal of Research of the National Institute of Standards and Technology,2011(5):785-796.
[22] Nie, L.;Suo, J.;Zou, P.;Feng, S. .Preparation and properties of biphasic calcium phosphate scaffolds multiply coated with HA/PLLA nanocomposites for bone tissue engineering applications[J].Journal of nanomaterials,2012(Pt.4):213549-1-213549-11.
[23] 徐国富,牟申周,周灵平,廖素三,尹志民,崔福斋.仿生增强制备聚乳酸基骨组织工程复合材料[J].湖南大学学报(自然科学版),2006(02):86-89.
[24] Hong ZK;Zhang PB;He CL;Qiu XY;Liu AX;Chen L;Chen XS;Jing XB .Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility[J].Biomaterials,2005(32):6296-6304.
[25] 任天斌,宋莹,冯玥,袁伟忠.热压-盐析法制备骨组织工程支架的工艺及性能表征米[J].中国组织工程研究与临床康复,2009(42):8281-8285.
[26] Lim KLK;Ishak ZAM;Ishiaku US;Fuad AMY;Yusof AH;Czigany T;Pukanzsky B;Ogunniyi DS .High density polyethylene/ultra high molecular weight polyethylene blend. II. Effect of hydroxyapatite on processing, thermal, and mechanical properties[J].Journal of Applied Polymer Science,2006(5):3931-3942.
[27] Ankur Gupta,Garima Tripathi,Debrupa Lahiri,Kantesh Balani.Compression Molded Ultra High Molecular Weight Polyethylene-Hydroxyapatite-Aluminum Oxide-Carbon Nanotube Hybrid Composites for Hard Tissue Replacement[J].材料科学技术(英文版),2013(06):514-522.
[28] H.Fouad,R.Elleithy,Othman Y.Alothman.Thermo-mechanical, Wear and Fracture Behavior of High-density Polyethylene/Hydroxyapatite Nano Composite for Biomedical Applications: Effect of Accelerated Ageing[J].材料科学技术(英文版),2013(06):573-581.
[29] 王珍萍,黄苏萍,周科朝.原位矿化法制备羟基磷灰石/高密度聚乙烯复合材料[J].粉末冶金材料科学与工程,2006(06):363-366.
[30] Wang H;Zuo Y;Zou Q;Cheng L;Huang D;Wang L;Li YB .Nano-Hydroxyapatite/Polyamide66 Composite Tissue-Engineering Scaffolds with Anisotropy in Morphology and Mechanical Behaviors[J].Journal of Polymer Science, Part A. Polymer Chemistry,2009(3):658-669.
[31] Jie W.;Li Y. .Tissue engineering scaffold material of nano-apatite crystals and polyamide composite[J].European Polymer Journal,2004(3):509-515.
[32] 周聪颖,李启期,魏杰,马健.纳米氟磷灰石-聚醚醚酮种植体骨整合效能研究[J].实用口腔医学杂志,2013(01):20-24.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%