对新型的两亲性生物降解接枝共聚物羟丙基纤维素接枝聚己内酯(HPC-g-PCL)的综合性能进行了测试.X射线衍射结果表明,接枝共聚有效地降低了PCL的结晶度,且随着PCL链段含量的降低,接枝共聚物的结晶度相应下降.DSC结果表明,与PCL均聚物相比,所得接枝共聚物的Tm、Tc和Xc均明显降低,且随着PCL链段含量的降低而不断下降;同时,与先熔融后冷却相比,室温下的共聚物溶液浇注膜,其结晶程度更完善.水解降解实验结合GPC曲线和SEM照片结果表明,与均聚物PCL相比,接枝共聚物更易发生降解.
参考文献
[1] | Vandamme T F;Ngombo Mukendi J F .[J].International Journal of Pharmaceutics,1996,132:153-163. |
[2] | Iooss P;Le-Ray AM;Grimandi G;Daculsi G;Merle C .A new injectable bone substitute combining poly(epsilon-caprolactone) microparticles with biphasic calcium phosphate granules.[J].Biomaterials,2001(20):2785-2794. |
[3] | Bogdanov B.;Van Den Bulcke A.;Verbeeck R.;Schacht E.;Vidts A. .Synthesis and thermal properties of poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers[J].Polymer: The International Journal for the Science and Technology of Polymers,1998(8/9):1631-1636. |
[4] | Choi Y K;Bae Y H;Kim S W .[J].Macromolecules,1998,31:8766-8774. |
[5] | Barakat I.;Grandfils C.;Jerome R.;Dubois P. .Poly(epsilon-caprolactone-b-glycolide) and poly(D,L-lactide-b-glycolide) diblock copolyesters: Controlled synthesis, characterization, and colloidal dispersions[J].Journal of Polymer Science, Part A. Polymer Chemistry,2001(2):294-306. |
[6] | Mecerreyes D.;Hedrick JL.;Detrembleur C.;Jerome R.;Miller RD. .Ring-opening polymerization of 6-hydroxynon-8-enoic acid lactone: Novel biodegradable copolymers containing allyl pendent groups[J].Journal of Polymer Science, Part A. Polymer Chemistry,2000(5):870-875. |
[7] | Michihiro Ii Jima;Yokio Nagasaki;Takashi Okada et al.[J].Macromolecules,1999,32:1140-1146. |
[8] | Wang CQ.;Dong YP.;Tan HM. .Biodegradable brushlike graft polymers. I. Polymerization of epsilon-caprolactone onto water-soluble hydroxypropyl cellulose as the backbone by the protection of the trimethylsilyl group[J].Journal of Polymer Science, Part A. Polymer Chemistry,2003(2):273-280. |
[9] | Khambatta F B;Warner F;Russel T et al.[J].Journal of POLYMER SCIENCE PART B:POLYMER PHYSICS,1976,14:1391. |
[10] | Pit C G;Chasalow Y M;Hibionada Y M et al.[J].Journal of Applied Polymer Science,1981,26:3779-3787. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%