以海藻酸钠(SA)和N-异丙基丙烯酰胺(NIPAM)为原料,采用水溶液聚合法制备了具有温度和pH值双重敏感性的海藻酸钠/聚(N-异丙基丙烯酰胺)水凝胶.在不同温度、不同pH值条件下,考察了单体浓度、交联剂用量、引发剂用量和反应温度对该凝胶溶胀度的影响,结果表明,凝胶有良好的温度和pH敏感性能,单体浓度、交联剂用量、引发剂用量和反应温度对凝胶的溶胀度均有较大影响.
参考文献
| [1] | Park TG .Temperature modulated protein release from pH/temperature-sensitive hydrogels.[J].Biomaterials,1999(6):517-521. |
| [2] | Zhang XZ.;Zhuo RX. .Preparation of fast responsive, thermally sensitive poly(N-isopropylacrylamide) gel[J].European Polymer Journal,2000(10):2301-2303. |
| [3] | Zhang J.;Peppas NA. .Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks[J].Macromolecules,2000(1):102-107. |
| [4] | Ivan Donati;Amelia Gamini;Gudmund Skjak-Brak;Amedeo Vetere;Cristiana Campa;Anna Coslovi;Sergio Paoletti .Determination of the diadic composition of alginate by means of circular dichroism: a fast and accurate improved method[J].Carbohydrate research,2003(10):1139-1142. |
| [5] | 许立新,王秀芬,张立群,刘力.海藻酸钠与N-异丙基丙烯酰胺接枝共聚及其温度、pH敏感特性研究[J].功能高分子学报,2005(02):204-209. |
| [6] | Liu G M;Yang S H;Zhang G Z .Conformational changes of poly(N-isopropylacrylamide) chains at air/water interface:Effects of temperature compression rate,and packing density[J].Journal of Physical Chemistry B,2007,111:3633. |
| [7] | Burha M;Carter Shawn M;Meyer Kevin J et al.Salt effects on poly (N-isopropylacrylamide) phase transition thermodynamics from NMR spectroscopy christopher[J].Journal of Physical Chemistry B,2008,112(34):10399. |
| [8] | Erbil C;Kazancioglu E;Uyanik N .Synthesis, characterization and thermoreversible behaviours of poly(dimethyl siloxane)/poly(N-isopropyl acrylamide) semi-interpenetrating networks[J].European Polymer Journal,2004(6):1145-1154. |
| [9] | Liu W;Zhang B;Lu WW;Li X;Zhu D;De Yao K;Wang Q;Zhao C;Wang C .A rapid temperature-responsive sol-gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel.[J].Biomaterials,2004(15):3005-3012. |
| [10] | Sanket D;Damian A M;Thomas M et al.Molecular modeling of thermo-responsive hydrogels:Observation of lower critical solution temperature[J].Soft Materials,2009,5:1514. |
| [11] | Hang J T;Huang S W;Cheng S X et al.Synthesis and characteristics of poly (N-isopropylacrylamide) /poly (N-isopropylacrylamide) interpenetrating polymer network as drug delivery system[J].Journal of POLYMER SCIENCE PART A:POLYMER CHEMISTRY,2004,42:1249. |
| [12] | Zhang J T;Cheng S X;Zhuo R X .Poly(vinyl alcohol)/poly (N-isopropylacrylamide) semi-interpenetrating polymer network hydrogels with rapid response to temperature changes[J].Colloid and Polymer Science,2003,281:580. |
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