采用溶胶凝胶法制备了具有生物活性的SiO2/聚乙醇酸-乳酸共聚物（PLGA）组织工程支架材料。该方法选用廉价的硅溶胶作为硅源制备二氧化硅凝胶,简单易行,大大降低了成本。用模拟体液（SBF）溶液对含有SiO2的PLGA支架材料进行体外模拟浸泡实验。从电子探针照片上可以看到制得的含有SiO2的PLGA多孔支架材料有着良好的微孔性,可用作组织工程支架。支架材料在SBF溶液中浸泡72 h后：电子探针元素分析发现支架材料表面沉积物中有大量钙、磷等元素;XRD图谱在2θ=32°处出现的结晶峰,证实了支架表面碳酸羟基磷灰石的形成。研究表明,所制得的含有SiO2的PLGA多孔支架材料具备良好生物活性。
The sol-gel technology was adopted as a new method to prepare bioactive SiO2/ poly（lactic acid-co-glycolic acid）（PLGA） scaffolds for the first time.Cheap silica sols were used as the source of silica.This method was simple and convenient.After prepared,the SiO2/PLGA scaffolds were immersed in the simulated body fluid（SBF） solution and were evaluated by electron probe,X-ray diffraction（XRD）,differential scanning calorimetry（DSC）.The pictures of electron probe showed that there are many holes in SiO2/PLGA scaffolds.This means that SiO2/PLGA scaffolds can be used as tissue engineering scaffolds.After SiO2/PLGA scaffolds were immersed in the SBF solution for 72h,poorly-crystal apatite was formed on the surface of the scaffolds.That is proved by the sediment of a great deal of calcium and phosphorus appeared on the surface of the scaffolds in electron probe pictures and the apatite’s dispersion apex at 2θ=32° in XRD patterns.The results suggest that SiO2/PLGA scaffolds are bioactive and the method is feasible.
参考文献
| [1] | 林高用,张栋,卢斌.非超临界干燥法制备块状SiO2气凝胶[J].中南大学学报（自然科学版）,2006(06):1117-1121. |
| [2] | 葛建华,吕宇鹏,周伟岗,马晓兵.PLGA组织工程支架材料在生理盐水中的降解性能[J].材料科学与工程学报,2009(02):198-200. |
| [3] | 杜锡光,陈莉,梁奇志,陈学思.羟基乙酸均聚物PGA的合成及表征[J].东北师大学报(自然科学版),2003(03):119-124. |
| [4] | 陈晓峰 .溶胶-凝胶生物活性材料的研制及其生物矿化性能研究[D].华南理工大学,2003. |
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