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hprt基因(次黄嘌呤鸟嘌呤磷酸核糖转移酶基因)由于其本身所具有的独特生物学特性,逐渐成为基因突变机制和修复机制理想的研究靶点,hprt基因突变分析法也逐渐成为很有价值并被广泛应用的生物剂量计. 系统地综述了hprt基因的生物学特性、 突变的检测方法学及其在辐射事故分析、放射治疗和宇航事业研究中的应用和进展.

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