利用含碘硅烷前体制备包裹BODIPY染料分子的纳米二氧化硅颗粒.颗粒中的碘原子通过重原子效应有效提高了BODIPY染料分子的系间窜越效率,进而提高了染料分子的单重态氧量子产率及光损伤DNA的能力.这一结果表明,含碘二氧化硅纳米颗粒可以成为众多荧光染料分子在光动力疗法领域应用的一个有效药物负载和输送体系.
参考文献
| [1] | Pushpan S K;Chandrashekar T K .Porphyrins in photodynamic therapy-A search for ideal photosensitizers[J].Current Medicinal Chemistry Anti-Cancer Agents,2002,2(20):187-207. |
| [2] | Macdonald I J;Dougherty T J .Basic principles of photodynamic therapy[J].Journal of Porphyrins and Phthalocyanines,2001,5:105129. |
| [3] | Byrne AT;O'Connor AE;Hall M;Murtagh J;O'Neill K;Curran KM;Mongrain K;Rousseau JA;Lecomte R;McGee S;Callanan JJ;O'Shea DF;Gallagher WM .Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment.[J].The British journal of cancer,2009(9):1565-1573. |
| [4] | Raymond Bonnett .Photosensitizers of the Porphyrin and Phthalocyanine Series for Photodynamic Therapy[J].Chemical Society Reviews,1995(1):19-33. |
| [5] | Joseph C K;Dwaine O C .Photochemical heavy-atom effects[J].Accounts of Chemical Research,1978,11(09):334-341. |
| [6] | Havlas Z;Michl J .Prediction of an inverse heavy-atom effect in H-C-CH2Br:Bromine substituent as a π acceptor[J].Journal of the American Chemical Society,2002,124:5606-5607. |
| [7] | Lower S K;ElSayed M A .The triplet state and molecular electronic processes in organic molecules[J].Chemical Reviews,1966,66:199-214. |
| [8] | McClure,D.S .Triplet-singlet transitions in organic molecules[J].Journal of Chemical Physics,1949,17:905-913. |
| [9] | Santos P F;Reis L V;Oliveira A S;Vieira Ferreira L F .Singlet oxygen generation ability of squarylium cyanine dyes[J].Journal of Photochemistry and Photobiology A:Chemistry,2003,160:159161. |
| [10] | Ramaiah D.;Chandrasekhar N.;Eldho NV.;Das S.;George MV.;Joy A. .HALOGENATED SQUARAINE DYES AS POTENTIAL PHOTOCHEMOTHERAPEUTIC AGENTS - SYNTHESIS AND STUDY OF PHOTOPHYSICAL PROPERTIES AND QUANTUM EFFICIENCIES OF SINGLET OXYGEN GENERATION[J].Photochemistry and Photobiology: An International Journal,1997(5):783-790. |
| [11] | Gorman, A;Killoran, J;O'Shea, C;Kenna, T;Gallagher, WM;O'Shea, DF .In vitro demonstration of the heavy-atom effect for photodynamic therapy[J].Journal of the American Chemical Society,2004(34):10619-10631. |
| [12] | Shane O. McDonnell;Michael J. Hall;Lorcan T. Allen;Annette Byrne;William M. Gallagher;Donal F. O'Shea .Supramolecular Photonic Therapeutic Agents[J].Journal of the American Chemical Society,2005(47):16360-16361. |
| [13] | Gallagher J F;Gallagher W M;O'Shea D F .Synthesis of BF2chelates of tetraarylazadipyrromethenes and evidence for their photodynamic therapeutic behavior[J].Chemical Communications,2002,17:1862-1863. |
| [14] | Ozlem, S;Akkaya, EU .Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy[J].Journal of the American Chemical Society,2009(1):48-49. |
| [15] | Atilgan S;Akkaya E U .Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy[J].Chemical Communications,2006,42:43984400. |
| [16] | Gallagher WM;Allen LT;O'Shea C;Kenna T;Hall M;Gorman A;Killoran J;O'Shea DF .A potent nonporphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia.[J].The British journal of cancer,2005(9):1702-1710. |
| [17] | Takatoshi Yogo;Yasuteru Urano;Yukiko Ishitsuka;Fumio Maniwa;Tetsuo Nagano .Highly Efficient and Photostable Photosensitizer Based on BODIPY Chromophore[J].Journal of the American Chemical Society,2005(35):12162-12163. |
| [18] | Ramaiah D.;Eckert I.;Arun KT.;Weidenfeller L.;Epe B. .Squaraine dyes for photodynamic therapy: Mechanism of cytotoxicity and DNA damage induced by halogenated squaraine dyes plus light (> 600 nm)[J].Photochemistry and Photobiology: An International Journal,2004(1):99-104. |
| [19] | Sehoon Kim;Tymish Y. Ohulchanskyy;Dhruba Bharali, .Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2009(29):12641-12644. |
| [20] | Aurore Loudet;Kevin Burgess .BODIPY Dyes and Their Derivatives:Syntheses and Spectroscopic Properties[J].Chemical Reviews,2007(11):4891-4932. |
| [21] | Gilles Ulrich;Raymond Ziessel;Anthony Harriman .The Chemistry of Fluorescent Bodipy Dyes:Versatility Unsurpassed[J].Angewandte Chemie,2008(7):1184-1201. |
| [22] | Sun, ZN;Wang, HL;Liu, FQ;Chen, Y;Tam, PKH;Yang, D .BODIPY-Based Fluorescent Probe for Peroxynitrite Detection and Imaging in Living Cells[J].Organic letters,2009(9):1887-1890. |
| [23] | Li Zeng;Evan W.Miller;Arnd Pralle;Ehud Y.Isacoff;Christopher J.Chang .A Selective Turn-On Fluorescent Sensor for Imaging Copper in Living Cells[J].Journal of the American Chemical Society,2006(1):10-11. |
| [24] | Bozdemir O A;Yilmaz M D;Akkaya E U .Convergent synthesis and light harvesting properties of dendritic boradiazaindacene (BODIPY) appended perylenediimide dyes[J].New Journal of Chemistry,2010,34:151155. |
| [25] | Cui AJ;Peng XJ;Fan JL;Chen XY;Wu YK;Guo BC .Synthesis, spectral properties and photostability of novel boron-dipyrromethene dyes[J].Journal of Photochemistry and Photobiology, A. Chemistry,2007(1):85-92. |
| [26] | Kuznetsova N A;Gretsova N S;Yuzhakova O A;Negrimovskii V M,Kaliya O L,Luk'yanets E A .New reagents for determination of the quantum efficiency of singlet oxygen generation in aqueous media[J].Russian Journal of General Chemistry,2001,71(01):39-45. |
| [27] | Khairutdinov R F .Photoluminescence and transient spectroscopy of free base porphyrin aggregates[J].Journal of Physical Chemistry B,1999,103:761-769. |
| [28] | Garcia G;Sarrazy V;Sol V;Le-Morvan C;Granet R;Alves S;Krausz P .DNA photocleavage by porphyrin-polyamine conjugates.[J].Bioorganic and medicinal chemistry,2009(2):767-776. |
| [29] | Baldursdo'ttir S G;Karlsen J;Roots J;T(φ)nnesen H H .Riboflavin-photosensitized changes in aqueous solutions of alginate.Rheological studies[J].Biomacromolecules,2003,4:429-436. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%