微循环条件下,红细胞的尺寸与血管相近,血液不能视为均质流体,其流动表现出较强的颗粒性,红细胞流变特性对血液流动有较大影响.本文使用高倍显微镜对微流控芯片矩形截面微通道内红细胞的流动和变形特性进行可视化观察研究,并使用高速CCD相机拍摄和捕捉了红细胞在微通道内的流动和变形过程.通过观察不同浓度、黏度和速度下红细胞的聚集性、变形性以及常见的运动形态,发现红细胞在低黏度、低速流动条件下表现为两面凹圆盘形,沿流动方向运动过程总是伴随着翻转与旋转;在高黏度、高速运动条件下,红细胞表现为扁平椭圆形、呈坦克履带式(TTM)前进.
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