用相转移法制备了用于引导骨再生的纳米磷灰石/聚酰胺66(n-HA/PA66)和载银纳米羟基磷灰石/二氧化钛/聚酰胺66(Ag-HA-TiO2/PA66)复合生物材料屏障膜,并通过与骨髓基质干细胞(BMSC)共培养评价了其体外生物相容性.扫描电子显微镜(SEM)观察显示,制备的复合材料膜为不对称多孔膜,一面是孔径小于10 μm的微孔层,另一面是孔径在30～200μm的大孔结构.四唑盐比色(MTT)和流式细胞术(FCM)试验结果表明:n-HA/PA66膜具有良好的细胞亲和力,有利于BMSC的黏附、生长和减少凋亡;Ag-HA-TiO2/PA66膜也具有良好的生物相容性,但加速了BMSC的凋亡.2种膜的结构和生物相容性能够满足引导骨组织再生膜材料的要求.
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