在前期研究基础上,本文分析了抗体结合/离解率、抗原浓度、脑脊液(Cerebrospinal fluid,CSF)体积流速、CSF体积、CSF壁面表面积、同位素半衰期、抗体注射剂量和放射性标记抗体的比活性等参数不确定性对放射免疫疗法治疗脑部肿瘤效果的影响,进一步分析了CSF体积流速随机因素的作用,研究结果对优化放射免疫治疗参数及制定临床治疗方案具有重要的参考价值.
参考文献
| [1] | 神经母细胞瘤的治疗进展[J].重庆医学,2007(15):1483-1485,1488. |
| [2] | Kramer K;Humm JL;Souweidane MM;Zanzonico PB;Dunkel IJ;Gerald WL;Khakoo Y;Yeh SD;Yeung HW;Finn RD;Wolden SL;Larson SM;Cheung NK .Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8.[J].Journal of Clinical Oncology,2007(34):5465-5470. |
| [3] | Lv Y;Cheung NK;Fu BM .A pharmacokinetic model for radioimmunotherapy delivered through cerebrospinal fluid for the treatment of leptomeningeal metastases.[J].The Journal of Nuclear Medicine,2009(8):1324-1331. |
| [4] | Silverberg GD;Heit G;Huhn S;Jaffe RA;Chang SD;Bronte-Stewart H;Rubenstein E;Possin K;Saul TA .The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.[J].Neurology: Official Journal of the American Academy of Neurology,2001(10):1763-1766. |
| [5] | Liu J .Uncertainty analysis for temperature prediction of biological bodies subject to randomly spatial heating.[J].Journal of Biomechanics,2001(12):1637-1642. |
| [6] | Barta P;Dazzan P .Hemispheric surface area: sex, laterality and age effects.[J].Cerebral cortex,2003(4):364-370. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%