利用定向冰晶-冷冻干燥法制备了具有定向孔隙结构的磷酸钙骨水泥支架材料,将两种具有不同降解速率的聚乳酸-羟基乙酸共聚物(PLGA)与磷酸钙骨水泥多孔支架进行多次浸润复合,以改善支架的力学性能.结果表明:PLGA与支架材料复合可大大提高复合支架材料的抗压强度,经过PLGA二次复合后,复合支架抗压强度可达6.37 MPa±0.54 MPa.经过PLGA复合的支架材料保持了复合前的孔隙结构,在孔的轴向方向上具有定向排列的开口孔隙,这些开口孔隙的存在有利于植入初期新生组织的长入.覆盖在骨水泥基体表面的PLGA膜可以增强基体的强度并弥补基体表面的缺陷,充填在孔隙内部的PLGA泡沫体可以很好地承受外加载荷,使复合支架材料具有较好的强度和韧性.
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