以Poly (GMA-DVB)微球为载体,将4,4'-偶氮双(4-氰基戊酸)(ACPA)连接到微球表面,然后以茶碱为模板分子,α-甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联荆,通过4,4'-偶氮双(4-氰基戊酸)(ACPA)引发聚合,在Poly (GMA-DVB)微球表面上均匀地接枝分子印迹聚合物,制备茶碱表面分子印迹聚合物微球.借助红外、电镜、粒度等表征方法对微球的制备进行了评价和探讨,采用静态法研究微球对荼碱的结合性能与分子识别特性.研究表明,分子印迹微球的接枝率随着载体微球表面环氧基含量的增加以及溶剂用量的减少而增大;分子印迹微球对茶碱具有特异的识别选择性与优良的结合亲和性,相对于咖啡碱识别选择性系数为2.81～3.62,室温吸附3h内可以达到吸附平衡.
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