通过分析骨涎蛋白和牙本质基质蛋白的功能域,设计合成了一种非胶原蛋白模拟多肽E8DS(EEEEEEEED SESSEEDR),引入胶原蛋白仿生矿化体系,共同调控磷酸钙晶体的矿化过程.圆二色谱和红外光谱分析结果表明,多肽E8DS可与钙离子和胶原分子通过静电作用相结合.使用稳态凝胶系统对多肽E8DS的分析结果表明,E8DS具有很强的调控钙磷盐矿化的能力.多肽的加入有助于胶原纤维的分子组装,增加了形核位点,促进了磷酸钙在胶原纤维表面矿化,使胶原纤维的矿化程度明最提高．
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