利用L-丙氨酸和三聚光气反应制备了N-羧基-丙氨酸-环内酸酐(NCA).以聚乙二醇单甲醚(MPEG)为原料,制备了端氨基聚乙二醇单甲醚(MPEG-NH2),并以此作为大分子引发剂,引发NCA开环聚合,合成了不同含量的聚L-丙氨酸-聚乙二醇嵌段共聚物(PLAM).利用IR、NMR、DSC等方法对共聚物结构进行了表征,同时利用圆二色光谱(CD)考察了聚合物材料在水溶液中的二级结构.结果表明,MPEG-NH2引发NCA开环聚合得到的是嵌段共聚物,CD测试结果表明共聚物在水溶液中主链以α-螺旋构象存在,聚L-丙氨酸分子中引入亲水性聚乙二醇单甲醚能够改善材料的亲水性能.
参考文献
| [1] | Kim HJ;Choi EY;Oh JS;Lee HC;Park SS;Cho CS .Possibility of wound dressing using poly(L-leucine)/poly(ethylene glycol)/poly(L-leucine) triblock copolymer.[J].Biomaterials,2000(2):131-141. |
| [2] | Yu BG.;Kataoka K.;Kwon G.;Okano T. .Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,1998(1/3):131-136. |
| [3] | Yu L;Kwon G S .[J].Pharmaceutical Research,2000,17(05):607-611. |
| [4] | Okamo T;Sakurai Y .[J].Journal of Controlled Release,2000,64:143-153. |
| [5] | Kong Soo Kim;Tae Kyoung Kim;Neil B. Graham .Controlled Release Behavior of Prodrugs Based on the Biodegradable Poly(L-glutamic acid) Microspheres[J].Polymer Journal,1999(10):813-816. |
| [6] | Barrera DA.;Lansbury PT.;Langer R.;Zylstra E. .COPOLYMERIZATION AND DEGRADATION OF POLY(LACTIC ACID CO-LYSINE)[J].Macromolecules,1995(2):425-432. |
| [7] | Kurita K;Yoshida A;Koyama Y .[J].MACROMOLECULES,1988,21:1579-1583. |
| [8] | Harada A.;Kataoka K. .Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium[J].Macromolecules,1998(2):288-294. |
| [9] | Greenwald RB.;Bolikal D.;Pendri A. .HIGHLY WATER SOLUBLE TAXOL DERIVATIVES - 7-POLYETHYLENE GLYCOL CARBAMATES AND CARBONATES[J].The Journal of Organic Chemistry,1995(2):331-336. |
| [10] | Yamaoka T;Tabata Y;Ikada Y .[J].Journal of Pharmaceutical Sciences,1994,83:601-606. |
| [11] | Pillai V N;Mutter M .[J].Journal of Organic Chemistry,1980,45:5364-5370. |
| [12] | William H Daly;Drew Poche .[J].Tetrahedron Letters,1988,29(46):5859-5862. |
| [13] | Yamashita Y;Iwaya Y;Ito K .[J].Die Makromolekulare Chemie,1975,176:1207-1216. |
| [14] | Holtzwarth G;Doty P .[J].Journal of the American Chemical Society,1965,87:218-223. |
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