以工业碱木质素、苯酚和甲醛为主要壁材,采用反相乳液聚合法制备了木质素酚醛基阿维菌素微球。通过扫描电镜、红外光谱、比表面及孔结构分析仪对微球结构进行表征,着重研究了壁材中木质素含量对微球结构和释放性能的影响。结果表明,制得的微球表面形貌呈粗糙球形,粒径在50μm~100μm,分布均匀。木质素含量较高时,微球表面结构较疏松,孔隙较多,释放速度较快。木质素含量约50%时得到的载药微球具有较致密的表面结构,在80%（体积分数）甲醇水溶液中,20 h内的释放率近40%,具有明显的缓释效果。
Abamectin-loaded microspheres were prepared by the inverse emulsion polymerization of an emulsified ligin-phenolic aqueous solution.The obtained microspheres were characterized by infrared spectroscopy,scanning electron microscope,and specific surface area analyzer.The main work focused on the influence of lignin content on the surface texture and release properties of microspheres.The results show that the obtained microspheres have rough surface and a narrow particle size distribution with a diameter of 50 μm~100 μm.The lignin content significantly influences the structure and release properties.The higher lignin content leads to a looser surface structure and a faster release rate.When the feeding lignin content reaches about 50%,the abamectin-loaded microspheres have a relatively denser surface and a slow-release rate.The released drugs are nearly up to 40% after vibrating in 80% ethanol solution for 20 hours.
参考文献
| [1] | 马丽杰,赵静.壳聚糖/木质素磺酸钠复凝聚法制备生物农药微胶囊[J].北京化工大学学报（自然科学版）,2006(06):51-56. |
| [2] | 韩志任,杜有辰,李刚,慕卫,刘峰.阿维菌素脲醛树脂微胶囊的制备及其缓释性能[J].农药学学报,2007(04):405-410. |
| [3] | Freitas S;Merkle HP;Gander B .Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(2):313-332. |
| [4] | Liu N;Zhang ST;Fu RW;Dresselhaus MS;Dresselhaus G .Fabrication and structure of carbon aerogel spheres prepared by inverse suspension/emulsion polymerization and ambient pressure drying[J].Journal of Applied Polymer Science,2007(5):2849-2855. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%