采用冷冻干燥法制备了丝素蛋白(SF)/纳米生物玻璃(NBG)复合多孔支架材料.并用XRD、FT-IR、SEM等对SF/NBG复合支架进行了结构与性能表征.结果表明,SF/NBG复合多孔支架孔连通性较好,孔径为150～300μm,孔隙率为80.6％～90.3％；同时NBG的加入促进了复合多孔支架中SF的构象部分由无规卷曲向β-折叠转变.复合多孔支架抗压强度和抗压模量相比于纯SF多孔支架有较大提高.采用模拟体液浸泡实验研究了复合支架的体外生物活性,并用XRD、FT-IR和FESEM对试样表面进行了表征.结果显示,复合多孔支架经模拟体液浸泡7d后,表面沉积出类骨羟基磷灰石(HA)层,NBG的加入能加快复合多孔支架表面沉积类骨HA的速度.研究结果显示SF/NBG复合多孔支架材料有望作为生物活性良好的骨组织修复材料.
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