O--季铵化--N, N--双十二烷基壳聚糖/胆固醇的混合单分子膜性质研究

材料研究学报, 2010, 24(3): 254-258.

O--季铵化--N, N--双十二烷基壳聚糖/胆固醇的混合单分子膜性质研究

华侨大学材料科学与工程学院福建省高校功能材料重点实验室厦门 361021

College of Material Science and Engineering, Huaqiao University, The Key Laboratory for Functional Materials of Fujian Higher Education, Xiamen 361021

基金项目: 国家自然科学基金20274013和20574024、福建省重大科技项目2002I004和2009H0030、福建省自然科学基金E0810019和
2009J01029及复旦大学聚合物分子工程教育部重点实验室开放课题。

关键词：有机高分子材料 , chitosan derivative , cholesterol , monolayer

Mixed Monolayers of O–Quaternized –N, N–Dilauryl Chitosan with Cholesterol

MING Rujing XIN Meihua LI Mingchun LIU Juezhao

Keywords： organic polymer materials , 壳聚糖衍生物 , 胆固醇 , 单分子膜

制备O--季铵化--N,N--双十二烷基壳聚糖, 用FTIR、EA、1H NMR对其进行表征, 并研究其与胆固醇的混合单分子膜性质。结果表明,随着胆固醇的摩尔分数从0.2增加到0.8, O--季铵化--N,N--双十二烷基壳聚糖/胆固醇混合单分子膜的极限分子占据面积
Aex及崩溃压πc逐渐减小。混合单分子膜两组分分子间的作用力从相互吸引作用转变为相互排斥作用的转折点出现在胆固醇的摩尔分数为0.4时。胆固醇的摩尔分数为0.2时, 混合单分子膜的相容性最好, 体系最稳定。

O–quaternized–N,N–dilauryl chitosan was prepared and characterized by FTIR, EA and 1H NMR. The behaviors of mixed monolayers of O–quaternized–N,N–dilauryl chitosan and cholesterol were studied. It showed that the limiting molecular area Aex and collapse pressure πc of mixed monolayers gradually decreased as the cholesterol molar ratio increased from 0.2 to 0.8. The values of ΔGexc changed from an attractive interaction to a repulsive interaction between O–quaternized–N,N–dilauryl chitosan and cholesterol with a critical point of cholesterol molar ratio 0.4 added in the mixed system, and the most stable state of mixed monolayers was observed at molar ratio of cholesterol 0.2.

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