采用鸡胚实验法,对几种稀土杂多配合物进行了鸡胚毒性及抗A3型流感病毒活性研究. 在对鸡胚无毒情况下,稀土杂多配合物对A3型流感病毒具有直接灭活作用 , 双十一钨硼镨钾盐K15[Pr(BW11O39)2]*15H2O对A3型流感病毒的抑制率高达90%, 抗病指数为69, 明显高于阳性对照药物病毒唑的抑制效果.
参考文献
[1] | Tsiang H;Atanasiu P;Chermann J C et al.Inhibition of rabies virus in vitro by the ammonium-5-tungsto-2-antimoniate[J].Journal of General Virology,1978,40(04):665. |
[2] | Pepin M;Blancou J .Ammonium-5-tungsto-2-antimoniate(HPA 23) can prevent fox rabies brief report[J].Archives of Virology,1985,83(04):327. |
[3] | Bussereau F;Picard M;Blancou J et al.Treatment of rabies in mice and foxes with antiviral compounds[J].Acta Virologica,1988,32(01):33. |
[4] | Hill C L;Weeks M S;Schinzi R F et al.Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates[J].Journal of Medicinal Chemistry,1990,33(10):2767. |
[5] | Yamase T;Fujita H;Fukushima K .Medical chemistry of polyoxometalates-Ⅰ. Potent antitumor activity of polyoxomolybdates on animal transplantable tumors and human cancer xenograft[J].Inorganica Chimica Acta,1988,151(01):15. |
[6] | 刘术侠;刘彦勇;王恩波 .13-钒镍(锰)杂多酸稀土盐的合成及镨盐抗肿瘤活性的研究[J].化学学报,1996,54(07):673. |
[7] | Ikeda S;Neyts J;Yamamoto N et al.In vitro acitivity of a novel series of polyoxosilicotungstates against human myxoherpes and retroviruses[J].Antiviral Chemistry & Chemotherapy,1993,4(05):253. |
[8] | Ikeda S;Nishiya S;Yamamoto A et al.Activity of the Keggin polyoxotungstate PM-19 against herpes simplex virus type 2 infection in immunosuppressed mice role of peritoneal macrophage activation[J].Journal of Medical Virology,1993,41(03):191. |
[9] | 王恩波.镧系元素钨硼杂多酸盐的合成及性质研究[J].高等学校化学学报,1991(12):1576. |
[10] | 倪嘉缵.稀土生物无机化学[M].北京:科学出版社,1995 |
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