为制备兼顾多孔性和高强度的水凝胶,本研究利用循环冷冻和冷冻干燥联用设计和制备了一系列聚乙烯醇水凝胶.从聚乙烯醇溶液的浓度、循环冷冻次数、单次冷冻时长三个方面对水凝胶的力学性能、内部微观形貌、含水量进行了研究.结果表明:以质量分数14％浓度的聚乙烯醇水溶液经过3次循环冷冻过程(16h冷冻,8h解冻)和液氮冷冻冰干后的支架,再经溶胀平衡后得到的PVA水凝胶具有最佳的力学性能,此时PVA水凝胶的拉伸强度为5.74MPa,断裂伸长率为347％;改变循环冷冻次数可有效地调节PVA水凝胶的含水量;水凝胶力学性能提高来源于体系结晶度的增大.
参考文献
| [1] | Francesca Cavalieri;Ester Chiessi;Raffaella Villa.Novel PVA-Based Hydrogel Microparticles for Doxorubicin Delivery[J].Biomacromolecules,20087(7):1967-1973. |
| [2] | Li JK.;Wu XS.;Wang N..Poly(vinyl alcohol) nanoparticles prepared by freezing-thawing process for protein/peptide drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,19981/3(1/3):117-126. |
| [3] | Kobayashi M;Chang YS;Oka M.A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus.[J].Biomaterials,200516(16):3243-3248. |
| [4] | Haoqun Hong;Haiyang Liao;Shujia Chen;Haiyan Zhang.Facile method to prepare self-healable PVA hydrogels with high water stability[J].Materials Letters,2014May.1(May.1):227-229. |
| [5] | Wan WK;Campbell G;Zhang ZF;Hui AJ;Boughner DR.Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.[J].Journal of biomedical materials research, Part B. Applied biomaterials,20026(6):854-861. |
| [6] | Gutierrez MC;Garcia-Carvajal ZY;Jobbagy M;Rubio T;Yuste L;Rojo F;Ferrer ML;del Monte F.Poly(vinyl alcohol) scaffolds with tailored morphologies for drug delivery and controlled release[J].Advanced functional materials,200717(17):3505-3513. |
| [7] | Takaaki Inada;Shu-Shen Lu.Inhibition of Recrystallization of Ice Grains by Adsorption of Poly (Vinyl Alcohol) onto Ice Surfaces[J].Crystal growth & design,20035(5):747-752. |
| [8] | Wang HY;Inada T;Funakoshi K;Lu SS.Inhibition of nucleation and growth of ice by poly(vinyl alcohol) in vitrification solution.[J].Cryobiology,20091(1):83-89. |
| [9] | Fu, Q.;Saiz, E.;Rahaman, M.N.;Tomsia, A.P..Bioactive glass scaffolds for bone tissue engineering: State of the art and future perspectives[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20117(7):1245-1256. |
| [10] | Holloway, J.L.;Lowman, A.M.;Palmese, G.R..The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels[J].Soft matter,20133(3):826-833. |
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