用化学共沉淀法合成了钙磷原子比（Ca/P）为1.50和1.67的磷石膏（PG）,用熔融聚合法制备四元氨基酸共聚物（PAA4）,用挤出发泡法制备了两种磷石膏/四元氨基酸共聚物（PG/PAA4）多孔复合材料。通过TGA、SEM、XRD、IR、EDS等对两种复合材料的组成结构进行了表征,并研究了复合材料在磷酸缓冲液（PBS）中的体外降解性能。结果表明：无机组分PG在两种复合材料中分布均一,质量分数均为60%左右;PG/PAA4复合材料的孔径为100～400μm,孔隙率在60%左右;多孔复合材料的有机和无机相之间有化学作用。PG/PAA4复合材料具有良好的体外降解性能,其失重率随PG钙磷比的增加而增加,降解液的pH值维持在6.9～7.4之间。PG/PAA4复合材料降解后,其表面沉积了片状钙磷化合物,推测该复合材料可能具有生物活性。
Phosphogypsum（PG） materials with the ratio of calcium and phosphorus（Ca/P） of 1.50 and 1.67 were synthesized by the chemical coprecipitation,poly（lactide-amino acid） copolymer（PAA4） was synthesized through the melt polycondensation,and two kinds of PG/PAA4 porous composites for the medical application with Ca/P of 1.50 and 1.67 were prepared by the extrusion foaming method.The morphology,microstructure and composition of the composites were characterized by TGA、 XRD、 IR、 SEM、 EDS,and the in vitro degradability of the composites were investigated through phosphate buffer solution（PBS）.The results show that the porous composites have good uniformity with the phosphogypsum of around 60%（mass fraction） dispersed in the PG/PAA4 composites.The porous composites have the pore size ranging from 100 to 400 μm with the porosity of 60%.Some chemical interactions occur between the inorganic（PG） and organic phases（PAA4） in the composites.The composites exhibit good degradability in PBS and their degradability is enhanced by the increase of the Ca/P of PG.No obvious change of pH value of the solution is found during the composites soaking into PBS,which ranges from 6.9 to 7.4.Presumably,the composites have bioactivity with the apatite deposited on their surfaces after soaking in PBS.
参考文献
| [1] | 周长忍, 丁 珊, 李立华. 可降解材料的制备及应用研究进展 [J]. 中国创伤骨骨科杂志, 2000, 2(4): 317-319. |
| [2] | 张国林, 吴秋华, 宋溪明, 等. 聚氨基酸共聚物合成研究进展 [J]. 高分子材料科学与工程, 2006, 22(4): 10-14. |
| [3] | 高建平, 游秀东, 于九皋. 聚合物/硫酸钙可吸收复合生物材料: 中国, 1392188. 2003-01-22. |
| [4] | 严永刚, 李 鸿, 吕国玉. 氨基酸共聚物-硫酸钙复合材料及制备方法: 中国, 101560326. 2009-10-21. |
| [5] | Tamimi F, Kumarasami B, Doillon C, et al. Brushite-collagen composites for bone regeneration [J]. Acta Biomaterialia, 2008, 4(5): 1315-1321. |
| [6] | Wen H B, Cui F Z, Feng Q L, et al. Microstructural investigation of the early external callus after diaphyseal fractures of human long bone [J]. Struct Biol, 1995, 114(2): 115-122. |
| [7] | Cui F Z, Wen H B, Su X W, et al. Microstructures of external periosteal callus of repaired femoral fracture in children [J]. Struct Biol, 1996, 117(3): 204-208. |
| [8] | 杜明奎, 毛克亚, 王继芳. β-磷酸三钙与α-半水硫酸钙降解研究进展 [J]. 国际骨科学杂志, 2008, 29(1): 6-7. |
| [9] | Raucci M G, Antò V D’, Guarino V, et al. Biomineralized porous composite scaffolds prepared by chemical synthesis for bone tissue regeneration [J]. Acta Biomater, 2010, 4(8): 4090-4099. |
| [10] | 严永刚, 曹 侠, 李 鸿. 多孔类骨磷灰石/聚酰胺复合材料的制备方法: 中国, 1994480. 2007-07-11. |
| [11] | 刘永磊, 李 鸿, 吕国玉, 等. n-HA/ 多元氨基酸共聚物复合材料的制备和界面研究 [J]. 功能材料, 2010, 41(4): 566-569. |
| [12] | 李 鸿, 李玉宝, 严永刚, 等, 多孔n-HA/ PA-6复合材料的制备及性能 [J]. 复合材料学报, 2008, 25(1): 64-68. |
| [13] | Li Haiyan, Chang Jiang. In vitro degradation of porous degradable and bioactive PHBV/ wollastonite composite scaffolds [J]. Polymer Degradation and Stability, 2005, 87(2): 301-307. |
| [14] | Orava E, Korventausta J, Rosenberg M, et al. In vitro degradation of porous poly(DL-lactide-co-glycolide) (PLGA)/bioactive glass composite foams with a polar structure [J]. Polymer Degradation and Stability, 2007, 92(1): 14-23. |
| [15] | 蓝仲薇, 李 瑛, 陈 华, 肖友发. 有机化学基础 [M]. 中国: 海洋出版社, 2004: 118-124. |
| [16] | 李 鸿, 南景天, 吕国玉, 等. 新型可降解α-TCP/多元氨基酸共聚物复合材料制备与表征 [J]. 复合材料学报, 2010, 27(4): 26-30. |
| [17] | Zou Chao, Weng Wenjian, Deng Xuliang, et al. Preparation and characterization of porous β-tricalcium phosphate/collagen composites with an integrated structure [J]. Biomaterials, 2005, 26(26): 5276-5284. |
| [18] | 肖秀峰, 黄琼瑜, 刘榕芳, 等. 纳米羟基磷灰石/聚合物多孔复合支架材料 [J]. 复合材料学报, 2008, 25(6): 39-46. |
| [19] | 宋江凤, 刘 咏, 张 莹. 水热法合成不同形貌羟基磷灰石 [J]. 粉末冶金材料科学与工程, 2010, 15(5): 505-510. |
| [20] | Jin H H, Min S H, Song Y K, et al.Degradation behavior of poly(lactide-co-glycolide)/β-TCP composites prepared using microwave energy [J]. Polymer Degradation and Stability, 2010, 95(9): 1856-1861. |
| [21] | 薛 明, 周大利, 曹巨辉, 等. 壳聚糖/磷灰石-硅灰石复合多孔支架材料的制备与性能 [J]. 复合材料学报, 2009, 26(3): 127-132. |
| [22] | Lei Y, Rai B, Ho K H, et al. In vitro degradation of novel bioactive polycaprolactone-20% tricalcium phosphate composite scaffolds for bone engineering [J]. Materials Science and Engineering, 2007, 27(2): 293-298. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%