用三偏磷酸钠(STMP)对透明质酸(HA)进行交联,制备出HA-STMP凝胶薄膜,研究了不同交联程度HA-STMP薄膜的吸水保水性能和体外降解性能.研究结果表明,实验中控制STMP与HA的结构单元比在1/5以上都可以得到成膜性能良好的交联薄膜;HA-STMP交联薄膜可以吸附自身质量7～10倍的水分,且随着交联程度的提高,薄膜的吸水能力下降,保水性能提高;交联改性能改善HA的耐降解性能,使高聚物在体内的存留时间延长,且耐降解性能随交联程度的增加而提高.
Hyaluronan(HA) is cross-linked with trisodium trimetaphosphate(STMP) as well as different crosslinked density HA-STMP hydrogel films are prepared and their water uptake and retention ability and degradation property in-vitro are studied.Results indicate that HA-STMP hydrogel films have good shape with more ratio of structural cell of hyaluronan and trisodium trimetaphosphate than 1/5.HA-STMP hydrogel films can adsorb 7～10 times weight water than themselves,and if their cross-linked density is raised,their water uptake and retention ability is increased.Cross-link can improve degradation-resist ability of HA,prolong time of polymer in vivo,and if their cross-linked density is raised,their degradation-resist ability is increased.
参考文献
| [1] | 张伟,闫翠娥.透明质酸及其衍生物药物载体[J].化学进展,2006(12):1684-1690. |
| [2] | Long Liu;Guocheng Du;Jian Chen;Maio Wang;Jun Sun .Influence of hyaluronidase addition on the production of hyaluronic acid by batch culture of Streptococcus zooepidemicus[J].Food Chemistry,2008(4):923-926. |
| [3] | Romagnoli M;Belmontesi M .Hyaluronic acid-based fillers: theory and practice.[J].Clinics in dermatology,2008(2):123-159. |
| [4] | Jae Kyung Kim;Periasamy Srinivasan;Jae Hun Kim;Jong-il Choi;Hyun Jin Park;Myung Woo Byun;Ju Woon Lee .Structural and antioxidant properties of gamma irradiated hyaluronic acid[J].Food Chemistry,2008(4):763-770. |
| [5] | 聂素云,卢文庆,邹孔标.交联透明质酸凝胶薄膜的制备和性能表征[J].南京师范大学学报（工程技术版）,2007(01):54-58. |
| [6] | V.Dulong;S.Lack;D.Le Cerf;L.Picton;J.P.Vannier;G.Muller .Hyaluronan-based hydrogels particles prepared by crosslinking with trisodium trimetaphosphate.Synthesis and characterization[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2004(1):1-6. |
| [7] | 陈景华,陈静涛,徐政,顾其胜.聚乙二醇制备的透明质酸衍生物的生物降解性[J].中国生化药物杂志,2007(02):98-101. |
| [8] | 陈连喜,熊康,傅杰,王钧.聚癸二酸酐/聚乳酸共混薄膜的制备和降解性能[J].武汉理工大学学报,2004(07):49-51. |
| [9] | 刘海峰,尹玉姬,毛津淑,姚康德,杨光辉,崔磊,曹谊林.壳聚糖-明胶-透明质酸薄膜的制备及其性能的研究[J].中国生物医学工程学报,2005(03):271-276. |
| [10] | Intraorbital Hyaluronic Acid for Enophthalmos[J].Ophthalmology,2008(6):1101-1101. |
| [11] | Scheibner KA;Lutz MA;Boodoo S;Fenton MJ;Powell JD;Horton MR .Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.[J].The Journal of Immunology: Official Journal of the American Association of Immunologists,2006(2):1272-1281. |
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