MicroRNA发现的研究现状及重离子辐照相关应用前景

原子核物理评论 , 2009, 26(2): 172-176.

MicroRNA发现的研究现状及重离子辐照相关应用前景

基金项目: 中国科学院"百人计划"项目(O760140BR0)

Progress on Finding Novel MicroRNAs and Expectation of Heavy Ion Irradiation Application in This Field

Keywords： microRNA(miRNA) , identification of novel miRNA , heavy ion irradiation

MicroRNA(miRNA)是一类大小为19-24个核苷酸的非编码RNA,它们通过与靶基因的信使RNA(mRNA)结合在转录后水平调节靶基因的表达,因而在广泛的生物学过程中发挥重要作用.首先从miRNA的获得和鉴定两方面对目前miRNA发现工作进行了概括,然后分析和总结了近年来人源miRNA发现工作的现状,最后提出有关新miRNA发现工作的新想法.

MicroRNAs(miRNAs) are one kind of small non-coding RNAs of 19-24 nucleotides that tran-scriptionally regulate the expression of target genes by binding to their mRNA and thus play a central role in gene regulation in a wide arrange of biological processes. In this paper, we reviewed the clone and identification of novel miRNAs, summarized recent work on novel human miRNA recognization, and proposed a potentially feasible way to discover more human miRNAs.

参考文献

[1]	Bartel D P.Cell,2004,116:281.
[2]	Pfeffer S,Zavolan M,Gr(a)sser F A,et al.Science,2004,304(5671):734.
[3]	Lee R C,Feinbaum R L,Ambros V.Cell,1993,75:843.
[4]	Reinhart B J,Slack F,Basson M,et al.Nature,2000,403:901.
[5]	Pasquinelli A E,Reinhart B J,Slack F,et al.Nature,2000,408:86.
[6]	Zhou D G,Luo Y P,Li S G.Biotechnology Bulletin,2005,5:20(in Chinese).(周冬根,罗玉萍,李思光.生物技术通报,2005,5:20.)
[7]	Sanger Institute.http://microrna.sanger.ac.uk/sequences/.
[8]	Griffiths-Jones S,Saini H K,Dongen S V,et al.Nucleic Acids Research,2008,36:D154.
[9]	Griffiths-Jones S,Grocock R J,Dongen S V,et al.Nucleic Acids Research,2006,D34:140.
[10]	Griffiths-Jones S.Nucleic Acids Research,2004,34:D109.
[11]	Tsuchiya S,Okuno Y,Tsujimoto G.Journal of Pharmacological Sciences,2006,101(6):267.
[12]	Berezikov E,Cuppen E,Plasterk R.Nature Genetics,2006,38(6):261.
[13]	Xia Shouxuan.Radiobiology(The First Edition).Beijing:Military Medicine Science Press.1998,1-21(In Chinese).(夏寿萱,放射生物学(第一版).北京:军事医学科学出版社,1998,1-21.)
[14]	Gao J,Yang T T,Qiu X C,et al.Chinese Journal of Cancer,2007,26(6):561(in Chinese).(高杰,杨彤涛,裘秀春等.癌症,2007,26(6):561.)
[15]	Beuvink I,Kolb F A,Budach W,et al.Nucleic Acids Research,2007,35(7):52.
[16]	Wang J F,Zhou H,Chen Y Q,et al.Nucleic Acids Research,2004,32(5):1688.
[17]	Lagos-Quintana M,Rauhut R,Lendecke W,et al.Science,2001,294(5543):853.
[18]	Berezikov E,Plasterk R H.Hum Mol Genet,2005,14:183.
[19]	Lai E C,Tomancak P,Williams R W,et al.Genome Biol,2003,4(7):42.
[20]	Lira L P,Glasner M E,Yekta S,et al.Science,2003,299(5612):1540.
[21]	Park W,Li J,Song R,et al.Current Biology,2002,12(17):1484.
[22]	Lewis B P,Shih I H,Jones-Rhoades M W,et al.Cell,2003,115(7):787.
[23]	Xie X,Lu J,Kulbokas E J,et al.Nature,2005,434(7031):338.
[24]	Nelson P T,Baldwin D A,Scearce L M,et al.Nature Methods,2004,1(2):1271.
[25]	Berezikov E,Tetering G V,Verheul M,et al.Genome Research,2006,16(10):1289.
[26]	Kim V N.Nature Reviews,2005,6:376.
[27]	Gramantieri L,Ferracin M,Fornari F,et al.Cancer Research,2007,67(13):6092.
[28]	Moschos S A,Williams A E,Perry M M,et al.BMC Genomics,2007,8(1):240.
[29]	Wassarman K M,Repoila F,Rosenow C,et al.Genes Development,2001,15(13):1637.
[30]	Yan N,Lu Y,Sun H,et al.Reproduction,2007,134(1):73.
[31]	Liu C G,Calin G A,Meloon B,et al.Proc Nat Acad Sci USA,2004,101(26):9740.
[32]	Lu J,Getz G,Miska E A,et al.Nature,2005,435(7043):834.
[33]	Negrini M,Ferracin M,Sabbioni S,et al.Journal of Cell Science,2007,120:1833.
[34]	Bentwich I,Avniel A,Karov Y,et al.Nature Genetics,2005,37(7):766.
[35]	Pfeffer S,Sewer A,Lagos-Quintana M,et al.Nature Methods,2005,2:269.
[36]	Westermann F,Afanasyeva E A.BMC Genomics,2008,9:52.
[37]	Ishii H,Saito T.Med Chem,2006,2:555.
[38]	Marsit C J,Eddy K,Kelsey K T.Cancer Res,2006,66:10843.
[39]	Zhou Xuefeng,Wang Guandong,Zhang Weixiong.Molecular Systems Biology,2007,3:103.
[40]	Maes O C,An J,Sarojini H,et al.Journal of Cellular Biochemistry,2008,105(3):824.

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