采用可溶粒子造孔法结合冷等静压成型技术,模拟扁骨的结构,制备了一种新型层状结构的多孔磷酸钙骨水泥组织工程支架材料,并用XRD和SEM等手段对其组成和结构进行了表征,用万能材料试验机测定了支架的抗压强度.结果表明,材料由致密层和多孔层构成,具有与扁骨类似的结构.其中致密层起到了增强作用,可以显著提高支架的强度.支架多孔层的孔隙率(77.26±1.99)%,孔隙直径在100～400 μm,决定于可溶盐晶粒的大小;致密层的孔隙率(20.78±0.56)%,主要是磷酸钙骨水泥固化过程中产生的微孔.
参考文献
| [1] | Xu HH;Burguera EF;Carey LE .Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures.[J].Biomaterials,2007(26):3786-3796. |
| [2] | Hollister SJ;Maddox RD;Taboas JM .Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints.[J].Biomaterials,2002(20):4095-4103. |
| [3] | Hutmacher DW .Scaffolds in tissue engineering bone and cartilage.[J].Biomaterials,2000(24):2529-2543. |
| [4] | Sun Wei;Lal Pallavi .Recent development on computer aided tissue engineering--a review.[J].Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice,2002(2):85-103. |
| [5] | Xu HH;Quinn JB .Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity.[J].Biomaterials,2002(1):193-202. |
| [6] | Ishikawa K;Miyamoto Y;Takechi M et al.Non-decay type fast-setting calcium phosphate cement:Hydroxyapatite putty containing an increased amount of sodium alginate[J].Journal of Biomedical Materials Research,1997,36(03):393-399. |
| [7] | 董浩,叶建东,王秀鹏.磷酸钙骨水泥/明胶复合组织工程支架材料的制备及其结构与性能[J].功能材料,2006(11):1805-1807,1811. |
| [8] | Simon CG Jr .Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility.[J].Biomaterials,2005(12):1337-1348. |
| [9] | Xu H H K;Simon G C.Self-hardening calcium phosphate cement-mesh composite:Reinforcement,macropores,and cell response[J].Journal of Biomedical Materials Research Part A,2004(69):267-278. |
| [10] | Hockin H. K. Xu;Janet B. Quinn;Shozo Takagi .Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement on mechanical properties[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(3):457-466. |
| [11] | Khairoun I;Driessens FC;Boltong MG;Planell JA;Wenz R .Addition of cohesion promotors to calcium phosphate cements.[J].Biomaterials,1999(4):393-398. |
| [12] | Ishaug S L;Crane G M;Miller M J.Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds[J].Journal of Biomedical Materials Research,1997(36):17-28. |
| [13] | Chen QZ;Wong CT;Lu WW;Cheung KM;Leong JC;Luk KD .Strengthening mechanisms of bone bonding to crystalline hydroxyapatite in vivo.[J].Biomaterials,2004(18):4243-4254. |
| [14] | Sepulveda P;Binner JG;Rogero SO;Higa OZ;Bressiani JC .Production of porous hydroxyapatite by the gel-casting of foams and cytotoxic evaluation.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2000(1):27-34. |
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