传统智能水凝胶作为药物栽体可控制药物的定点、定时、定量释放,具有提高药效、靶向,减少给药频率,增加安全性等优点.但由于存在响应速率慢的缺点而大大限制其应用.因此,近年来围绕提高智能水凝胶给药的响应速率的研究非常活跃,展示了广阔的应用前景.文中综述了快速响应水凝胶的类型、制备原理与给药系统中的应用进展,并指出其缺点及发展方向.
参考文献
[1] | Xian -Zheng Zhang;Yi-Yan Yang;Tai-Shung Chung .Preparation and Characterization of Fast Response Macroporous Poly(N-ispropylacrylamide)Hydrogels[J].Langmuir: The ACS Journal of Surfaces and Colloids,2001(20):6094-6099. |
[2] | Joao Maia;Maria H.Gil;Lino Ferreira;Rui Carvalho;Manuel A.Ramos .Synthesis and characterization of new injectable and degradable dextran-based hydrogels[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(23):9604-9614. |
[3] | Dorkoosh FA;Coos Verhoef J;Ambagts MH;Rafiee Tehrani M;Borchard G;Junginger HE .Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin.[J].European journal of pharmaceutical sciences,2002(5):433-439. |
[4] | Dorkoosh FA;Stokkel MPM;Blok D;Borchard G;Rafiee-Tehrani A;Verhoef JC;Junginger HE .Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(2):199-206. |
[5] | Polnok A;Verhoef JC;Borchard G;Sarisuta N;Junginger HE .In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels.[J].International Journal of Pharmaceutics,2004(2):303-310. |
[6] | Yin L;Fei L;Cui F;Tang C;Yin C .Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks.[J].Biomaterials,2007(6):1258-1266. |
[7] | Lichen Yin;Likun Fei;Cui Tang .Synthesis,characterization,mechanical properties and biocompatibility of interpenetrating polymer network-super-porous hydrogel containing sodium alginate[J].Polymer international,2007(12):1563-1571. |
[8] | H.L.Abd El-Mohdy;Agnes Safrany .Preparation of fast response superabsorbent hydrogels by radiation polymerization and crosslinking of N-isopropylacrylamide in solution[J].Radiation Physics and Chemistry,2008(3):273-279. |
[9] | Ferreira L;Gil MH;Cabrita AMS;Dordick JS .Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels[J].Biomaterials,2005(23):4707-4716. |
[10] | Xian-Zheng Zhang;Ren-Xi Zhuo .Synthesis and properties of thermosensitive poly(N-isopropylacrylamide-co-methyl methacrylate) hydrogel with rapid response[J].Materials Letters,2002(1/2):5-9. |
[11] | Si-Xue Cheng;Jian-Tao Zhang;Ren-Xi Zhuo .Macroporous poly(N-isopropylacrylamide) hydrogels with fast response rates and improved protein release properties[J].Journal of biomedical materials research, Part B. Applied biomaterials,2003(1):96-103. |
[12] | Tan BH;Ravi P;Tan LN;Tam KC .Synthesis and aqueous solution properties of sterically stabilized pH-responsive polyampholyte microgels[J].Journal of Colloid and Interface Science,2007(2):453-463. |
[13] | Tan JPK;Tam KC .Application of drug selective electrode in the drug release study of pH-responsive microgels[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2007(1):87-94. |
[14] | Chan Y;Bulmus V;Zareie MH;Byrne FL;Barner L;Kavallaris M .Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(2):197-207. |
[15] | Kohli E;Han HY;Zeman AD;Vinogradov SV .Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2007(1/2):19-27. |
[16] | Patnaik S;Sharma AK;Garg BS;Gandhi RP;Gupta KC .Photoregulation of drug release in azo-dextran nanogels.[J].International Journal of Pharmaceutics,2007(1/2):184-193. |
[17] | Vinogradov SV;Zeman AD;Batrakova EV;Kabanov AV .Polyplex Nanogel fort-nulations for drug delivery of cytotoxic nucleoside analogs[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(1):143-157. |
[18] | Sahiner N;Alb AM;Graves R;Mandal T;McPherson GL;Reed WF;John VT .Core-shell nanohydrogel structures as tunable delivery systems[J].Polymer: The International Journal for the Science and Technology of Polymers,2007(3):704-711. |
[19] | Lee SB.;Ha DI.;Cho SK.;Kim SJ.;Lee YM. .Temperature/pH-sensitive comb-type graft hydrogels composed of chitosan and poly(N-isopropylacrylamide)[J].Journal of Applied Polymer Science,2004(4):2612-2620. |
[20] | Zhang H;Chu LY;Li YK;Lee YM .Dual thermo- and pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with rapid response behaviors[J].Polymer: The International Journal for the Science and Technology of Polymers,2007(6):1718-1728. |
[21] | Xiaolin Li;Jian Ji;Jiacong Shen .Synthesis of hydroxyl-capped comb-like poly(ethylene glycol) to develop shell cross-linkable micelles[J].Polymer: The International Journal for the Science and Technology of Polymers,2006(6):1987-1994. |
[22] | Kim JH.;Lee SB.;Kim SJ.;Lee YM. .Rapid temperature/pH response of porous alginate-g-poly(N-isopropylacrylamide) hydrogels[J].Polymer: The International Journal for the Science and Technology of Polymers,2002(26):7549-7558. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%