聚合物水凝胶是由亲水性聚合物链通过物理作用或化学键作用形成的三维网络结构,在受到环境变化刺激时会产生响应性,因而作为药物控释载体广泛应用于医药领域。文中介绍了可控释药系统的类型及其主要影响因素,综述了可控释药数学模型的发展与应用,比较性分析了经验/半经验模型与机理模型,并展望了未来的发展方向。
Polymeric hydrogels are three-dimensional polymer networks in which individual hydrophilic polymer chains are connected,either by physical association or by chemical bonds.Once stimulated by environmental changes,such as the variation of pH or temperature,hydrogels will respond intelligently and achieve a new equilibrium state in a short time,so they have a wide application in pharmaceutical domain as ideal carriers for drug controlled release.This paper introduced different types of controlled release systems and their major influencing factors,reviewed the development and application of mathematical models describing the drug release processes,comparatively analyzed empirical/semi-empirical models and mechanism models,and presented development trends.
参考文献
| [1] | Chan AW;Neufeld RJ .Modeling the controllable pH-responsive swelling and pore size of networked alginate based biomaterials.[J].Biomaterials,2009(30):6119-6129. |
| [2] | Siepmann J;Siepmann F .Mathematical modeling of drug delivery.[J].International Journal of Pharmaceutics,2008(2):328-343. |
| [3] | Siepmann J;Faisant N;Akiki J;Richard J;Benoit JP .Effect of the size of biodegradable microparticles on drug release: experiment and theory[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(1):123-134. |
| [4] | Peppas NA;Hilt JZ;Khademhosseini A;Langer R .Hydrogels in biology and medicine: From molecular principles to bionanotechnology[J].Advanced Materials,2006(11):1345-1360. |
| [5] | Kiil S.;Dam-Johansen K. .Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(1):1-21. |
| [6] | Teles, H.;Vermonden, T.;Eggink, G.;Hennink, W.E.;de Wolf, F.A. .Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(2):298-303. |
| [7] | Ferrero C.;Bravo I.;Jimenez-Castellanos MR. .Drug release kinetics and fronts movement studies from methyl methacrylate (MMA) copolymer matrix tablets: effect of copolymer type and matrix porosity[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(1/2):69-82. |
| [8] | Pillay V;Fassihi R .Electrolyte-induced compositional heterogeneity: a novel approach for rate-controlled oral drug delivery.[J].Journal of Pharmaceutical Sciences,1999(11):1140-1148. |
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