利用胆固醇琥珀酸单酯对壳聚糖进行仿生功能化修饰,并对改性后产物进行了红外与核磁表征。同时对所合成的一系列壳聚糖衍生物进行矿化行为研究,结果表明,经胆固醇琥珀酸单酯修饰后的壳聚糖具有诱导类骨磷灰石形成的效果;随着胆固醇修饰程度的提高,诱导类骨磷灰石形成的作用加强,且使所沉积的磷灰石呈现出类生物骨内的有序堆积。
Cholesterol-modified chitosan conjugate with succinyl linkages（CHCS） was synthesized and characterized by Fourier transform infrared（FT-IR） and proton nuclear magnetic resonance（1H NMR）.The mineralization behaviors of CHCS were performed with a rapid and facile approach.Results revealed that CHCS have the ability of guided the apatite which similar to organisms＇ bone formation.With the ratio of cholesterol grafted increased the effect of CHCS guidance of bone-like apatite formation strengthened.And the deposited apatite present an order accumulated was similar to organisms＇ bone.
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