基因治疗是用于人类疾病治疗的一种新方法.基因载体系统是基因治疗面临的一个严峻挑战.基因载体包括病毒载体和非病毒载体,目前基因治疗中使用的主要是病毒载体.病毒载体具有转染率高的优点,但是却存在着安全性差等缺点,因此非病毒载体越来越受到关注.纳米颗粒是一种很有研究潜力的非病毒载体,其中基于天然高分子材料的纳米颗粒基因载体具有许多优良的特性.主要就天然高分子纳米颗粒的研究现状进行了综述.
参考文献
| [1] | MacRae EJ;Giannoudis A;Ryan R;Brown NJ;Hamdy FC;Maitland N;Lewis CE .Gene therapy for prostate cancer: current strategies and new cell-based approaches.[J].The Prostate,2006(5):470-494. |
| [2] | Jonathan C Daniel et al.Gene therapy of lung cancer[J].Seminars in Surgical Oncology,2003,21:196. |
| [3] | Anas El-Aneed .An overview of current delivery systems in cancer gene therapy[J].Journal of Controlled Release,2004,94:1. |
| [4] | Foley R;Lawler M;Hollywood D .Gene-based therapy in prostate cancer.[J].The lancet oncology,2004(8):469-479. |
| [5] | 杜仕国,施冬梅,韩其文.纳米颗粒的液相合成技术[J].粉末冶金技术,2000(01):46-50. |
| [6] | Zhu S H;Huang B Y;Zhou K C et al.Hydroxyapatite nanoparticles as a novel gene carrier[J].Journal of Nanoparticle Research,2004,6:307. |
| [7] | Carsten Kneuer;Mohammad Sameti;Eleonore G Haltner et al.Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA[J].International Journal of Pharmaceutics,2000,196:257. |
| [8] | Jon Dobson .Magnetic Nanoparticles for Drug Delivery[J].Drug Development Research,2006(1):55-60. |
| [9] | 胡云霞,原续波,张晓金,常津.阳离子多聚物纳米基因载体系统的研究进展[J].北京生物医学工程,2003(04):299-302. |
| [10] | Gil-Jae Jeong;Hyang-Min Byun;Jung Mogg Kim et al.Biodistribution and tissue expression kinetics of plasmid DNA complexed with polyethylenimines of different molecular weight and structure[J].Journal of Controlled Release,2007,118:118. |
| [11] | Gomez-Valades AG;Molas M;Vidal-Alabro A;Bermudez J;Bartrons R;Perales JC .Copolymers of poly-L-lysine with serine and tryptophan form stable DNA vectors: implications for receptor-mediated gene transfer[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(1):277-291. |
| [12] | Liu ZH;Li MY;Cui DF;Fei J .Macro-branched cell-penetrating peptide design for gene delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(3):699-710. |
| [13] | 郭荣,邹萍,陆华中.非病毒型纳米载体在基因治疗中的研究现状及展望[J].国外医学(生物医学工程分册),2002(02):77-81. |
| [14] | Shoichiro Asayama;Toshihiro Akaike;Atsushi Maruyama .Bi-phasic polycation for the DNA carrier responding to endosomal pH[J].Colloids and Sudaces B:Biointedaees,2001,22:183. |
| [15] | Lee KY.;Kim YH.;Jo WH.;Jeong SY.;Kwon IC. .Preparation of chitosan self-aggregates as a gene delivery system[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,1998(2/3):213-220. |
| [16] | Hyuk Sang Yoo;Jung Eun Lee;Hesson Chung et al.Selfassembled nanoparticles containing hydrophobically modified glycol chitosan for gene delivery[J].Journal of Controlled Release,2005,103:235. |
| [17] | Thanou M;Florea BI;Geldof M;Junginger HE;Borchard G .Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines.[J].Biomaterials,2002(1):153-159. |
| [18] | Tae Hee Kim;Jong Eun Ihm;Yun Jaie Choi et al.Efficient gene delivery by urocanic acid-modified chitosan[J].Journal of Controlled Release,2003,93:389. |
| [19] | Mao Haiquan;Krishnendu Roy;Vu L et al.ChitosanDNA nanoparticles as gene carriers:synthesis,characterization and transfection efficiency[J].Journal of Controlled Release,2001,70:399. |
| [20] | 李惠,高荣,武梅,付满良,吴凯源,杨毅,王秀英,王泽洲,刘世贵.壳聚糖纳米颗粒包裹对鼠白细胞介素2基因表达和调节小鼠免疫效应的影响[J].生物医学工程学杂志,2004(06):947-952. |
| [21] | Roland Bodmeier;Chen Huagang;Ornlaksana Paeratakul .A novel approach to the oral delivery of micro or nanoparticles[J].Pharmaceutical Research,1989,6(05):413. |
| [22] | Koping-Hoggard M;Mel'nikova Y S;Varum K M et al.Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo[J].J Oene Medicine,2003,5:130. |
| [23] | Mona Guptaa;Ajay Kumar Gupta .Hydrogel pullulan nano particles encapsulating pBUDLacZ plasmid as an efficient gene delivery carrier[J].Journal of Controlled Release,2004,99:157. |
| [24] | 肖苏尧,刘选明,童春义,刘俊,唐冬英,赵李剑.多聚赖氨酸淀粉纳米颗粒基因载体的研制及应用[J].中国科学B辑,2004(06):473-477. |
| [25] | 刘俊,刘选明,肖苏尧,童春意,唐冬英,赵李剑.基于超声波下淀粉纳米颗粒作载体的基因转导[J].高等学校化学学报,2005(04):634-637. |
| [26] | 蒋革,冯宝民,廉荣一.明胶-多聚乙烯亚胺-DNA复合物的构建及对细胞的体外转染[J].延边大学医学学报,2005(04):237-240. |
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