在胶原溶胀液中加入壳聚糖,形成了胶原/壳聚糖复合溶胀液(1.5%质量分数,下同),考察了胶原与壳聚糖的质量比、剪切速率、温度等因素对复合溶胀液表观黏度的影响规律.实验结果表明,复合胶原溶胀液具有假塑性流体的特性.随着复合溶胀液中壳聚糖含量增多,体系pH值逐渐增大,向胶原溶胀液的等电点靠近,使分子逐渐卷曲,流体力学等价球变小,其表观黏度逐渐减小,对剪切应力的敏感性逐渐减小.另外,随着体系温度的升高,复合溶胀液的非牛顿指数值不断增大,其流动性趋于牛顿流体.
参考文献
| [1] | Keilhoff G;Stang F;Wolf G;Fansa H .Bio-compatibility of type I/III collagen matrix for peripheral nerve reconstruction.[J].Biomaterials,2003(16):2779-2787. |
| [2] | Angele P;Abke J;Kujat R;Faltermeier H;Schumann D;Nerlich M;Kinner B;Englert C;Ruszczak Z;Mehrl R;Mueller R .Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices.[J].Biomaterials,2004(14):2831-2841. |
| [3] | Charulatha V;Rajaram A .Influence of different crosslinking treatments on the physical properties of collagen membranes.[J].Biomaterials,2003(5):759-767. |
| [4] | Itoh S;Takakuda K;Kawabata S;Aso Y;Kasai K;Itoh H;Shinomiya K .Evaluation of cross-linking procedures of collagen tubes used in peripheral nerve repair.[J].Biomaterials,2002(23):4475-4481. |
| [5] | Sionkowska A;Wisniewski M;Skopinska J;Kennedy CJ;Wess TJ .Molecular interactions in collagen and chitosan blends.[J].Biomaterials,2004(5):795-801. |
| [6] | Wang XH;Li DP;Wang WJ;Feng QL;Cui FZ;Xu YX;Song XH;van der Werf M .Crosslinked collagen/chitosan matrix for artificial livers.[J].Biomaterials,2003(19):3213-3220. |
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