Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions

武汉理工大学学报-材料科学版(英文版), 2005, 20(z1): 220-222.

^1, , ^2, , ^3, , ^4, , ^5, , ^6,

1.Nanotechnology Research Institute,National Institute of Advanced Industrial Science and Technology (AIST),Central 5,1-1-1 Higashi,Tsukuba 305-8565,Japan

2.School of Science and Engineering,Waseda University,3-4-1 Okubo,Shinjuku 169-8555,Japan

3.School of Science and Engineering,Waseda University,3-4-1 Okubo,Shinjuku 169-8555,Japan

4.Nanotechnology Research Institute,National Institute of Advanced Industrial Science and Technology (AIST),Central 5,1-1-1 Higashi,Tsukuba 305-8565,Japan

5.Institute for Human Science and Biomedical Engineering,National Institute of Advanced Industrial Sdence aml Technology (AIST),Central 6,1-1-1 Higashi,Tsukuba 305-8566,Japan

6.Institute for Human Science and Biomedical Engineering,National Institute of Advanced Industrial Sdence aml Technology (AIST),Central 6,1-1-1 Higashi,Tsukuba 305-8566,Japan

基金项目: Industrial Technology Research Grant Program New Energy and Industrial Technology Development Organization (NEDO) of Japan

Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions

Keywords： apatite

A synthetic polymer with a laminin-apatite composite layer on its surface would be useful as a percutaneous device. The preparation of such a composite was attempted in the present study using poly ( ethylene terephthalate ) (PET) and polyethylene ( PE ) as the synthetic polymer. PET and PE plates and those pretreated with an oxygen plasma were alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable ealcium phosphate solution supplemented with laminin ( LCP solution ). The PET and PE plates pretreated with an oxygen plasma formed a uniform and continuous layer of a laminin- apatite composite on their surfaces. In contrast, the PET and PE plates that had not been pretreated with an oxygen plasma did not form a continuous layer of a laminin-apatite composite on their surfaces. The hydrophilic functional groups on the PET and PE surfaces introduced by the plasma treatment were responsible for the successful laminin-apatite composite coating.

参考文献

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Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions

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