为了研究功能性碳纳米管在动物活体内的代谢和组织器官分布特征,采用放射性同位素99mTc标记二乙烯三胺五乙酸(DTPA)接枝的多壁碳纳米管(MWCNTs),经静脉途径注入家兔体内,以单光子发射计算机体层成像系统(SPECT)和井型γ计数器收集一定时间段其体内心脏、肺、肝脏、肾等各器官的放射性强度,同时对家兔尿液离心沉淀物进行电镜分析.结果显示,经静脉注射MWCNT-DTPA-99mTc后主要分布在心脏、肝脏、脾脏和肾脏,随着时间的延长可缓慢被机体清除,在尿液电镜分析中发现了以原型排出的MWCNTs,表明MWCNTs可通过家兔泌尿系统排出体外.
参考文献
| [1] | Iijima S .Helical microtubules of graphitic carbon[J].Nature,1991,354(6348):56-58. |
| [2] | 成会明.纳米碳管制备、结构、物性及应用[M].北京:化学工业出版社,2002 |
| [3] | Otto Zhou;Hideo Shimoda;Bo Gao;Les Fleming .Materials science of carbon nanotubes:fabrication,integration,and properties of macroscopic structures of carbon nanotubes[J].Accounts of Chemical Research,2002(12):1045-1053. |
| [4] | Vasilios Georgakilas;Nikos Tagmatarchis;Davide Pantarotto;Alberto Bianco;Jean-Paul Briand;Maurizio Prato .Amino acid functionalisation of water soluble carbon nanotubes[J].Chemical communications,2002(24):3050-3051. |
| [5] | Pantarotto D;Singh R;McCarthy D et al.Funtionalised carbon nanotubes for plasmid DNA gene delivery[J].Angewandte Chemie International Edition,2004,43:5242-5246. |
| [6] | 孙岚,张英鸽,杨留中.纳米活性炭在小鼠体内的分布、存留及淋巴靶向性[J].军事医学科学院院刊,2005(04):349-351. |
| [7] | Klumpp C;Kostarelos K;Prato M;Bianco A .Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics[J].Biochimica et biophysica acta. Biomembranes,2006(3):404-412. |
| [8] | Rawat M;Singh D;Saraf S;Saraf S .Nanocarriers: Promising vehicle for bioactive drugs[J].Biological & pharmaceutical bulletin,2006(9):1790-1798. |
| [9] | Yi Lin;Huaping Li;K.A.Shiral Fernando;Liangwei Qu;Wei Wang;Lingrong Gu;Bing Zhou;Ya-Ping Sun .Advances toward bioapplications of carbon nanotubes[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2004(4):527-541. |
| [10] | CINDY H. DUBIN .Special Delivery: PHARMACEUTICAL COMPANIES AIM TO TARGET THEIR DRUGS WITH NANO PRECISION[J].Mechanical engineering,2004(9):10-12. |
| [11] | Alberto Bianco;Johan Hoebeke;Kostas Kostarelos .Carbon nanotubes:On the road to deliver[J].Current Drug Delivery,2005,2:253-259. |
| [12] | Vasilios Georgakilas;Dimitrios Gournis;Michael A. Karakassides .Organic derivatization of single-walled carbon nanotubes by clays and intercalated derivatives[J].Carbon: An International Journal Sponsored by the American Carbon Society,2004(4):865-870. |
| [13] | Leoni L;Desai TA .Micromachined biocapsules for cell-based sensing and delivery.[J].Advanced drug delivery reviews,2004(2):211-229. |
| [14] | Wang H F;Wang J;Deng X et al.Biodistribution of singlewall carbon nanotubes in mice[J].Journal of Nanoscience and Nanotechnology,2004,4:1019-1024. |
| [15] | 徐勇勇.医学统计学[M].北京:高等教育出版社,2002 |
| [16] | Ravi Singh;Davide Pantarotto;Lara Lacerda;Giorgia Pastorin;Cedric Klumpp;Maurizio Prato;Alberto Bianco;Kostas Kostarelos .Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers[J].Proceedings of the National Academy of Sciences of the United States of America,2006(9):3357-3362. |
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