创面修复材料对人体皮肤各种损伤的痊愈尤为重要,一直是临床研究的重要课题.介绍了3个发展阶段划分的新观点,即传统敷料、生物敷料及复合型敷料和组织工程化皮肤,并指出了各阶段存在的问题.其中组织工程原理为研究创面修复材料提供了广阔的前景,目前的研究工作多基于此理论,最后总结了今后的研发方向.
Wound repair materials for a variety of skin injury recovery are particularly important,and have always been an important topic for clinical research.Three stages of new perspectives are introduced,namely,traditional dressings,biological dressings and composite dressings and tissue-engineered skin.And the problems of every stage are pointed out.The principle of tissue engineering on which the current research bases provides a broad prospect for the study of wound healing.Finally future research directions are summed up.
参考文献
| [1] | 郑峻松;吴军;马兵 等.CTLA4Ig基因转染猪皮异种移植体外实验研究[J].第三军医大学学报,2003,23(07):762. |
| [2] | 黄沙,金岩,邓天政,吴红,刘涛,刘建明.复合缓释微球的胶原膜促创面愈合的实验研究[J].中国修复重建外科杂志,2006(02):161-164. |
| [3] | 尹安,谷莉,陆将,何丽丽.胶原包被的微粒皮肤移植修复创面的临床研究[J].中国医疗前沿,2007(22):32-33. |
| [4] | 蒋玉燕,毕忆群,蒋建国.壳聚糖生物流体敷料膜对各类创面愈合的临床效应[J].中国组织工程研究与临床康复,2007(01):164-166. |
| [5] | 夏运松,吴振声,张艺.壳聚糖+重组表皮生长因子在皮肤创面的应用[J].中国实用医药,2007(31):80-81. |
| [6] | 张诗虎,王海林,倪峰,林宏云.海藻酸药物缓释纤维敷料临床应用研究[J].医疗卫生装备,2007(10):65-65. |
| [7] | Abel R;Schablowski M;Rupp R;Gerner HJ .Gait analysis on the treadmill - monitoring exercise in the treatment of paraplegia.[J].Spinal cord: the official journal of the International Medical Society of Paraplegia,2002(1):17-22. |
| [8] | 付小兵,程飚,盛志勇.生长因子应用于临床创伤修复--十年的主要进展与展望[J].中国修复重建外科杂志,2004(06):508-512. |
| [9] | 王丽娟,吴冬青,侯悦,韩红霞,徐晓东,董霜,颜霞.纳米银无菌敷料在造血干细胞移植后皮肤损伤中的应用[J].护理研究,2008(14):1306-1306. |
| [10] | Rustogi R;Mill J;Fraser JF;Kimble RM .The use of Acticoat in neonatal burns.[J].Burns: Including Thermal Injury,2005(7):878-882. |
| [11] | Wright J B;Lam K;Buret A G et al.Early healing events in a porcine model of contaminated wounds.Effects of nanocrystalline silver on matrixmetallop roteinases,cellapop tosis and healing[J].Wound Repair and Regeneration,2002,10:141. |
| [12] | Green H;Kehinde O;Thomas J .Growth of cultured human epidermal cells into multiple epithetlia suitable for grafting[J].Proceedings of the National Academy of Sciences(USA),1979,76(11):5665. |
| [13] | Suzuki T;Ui K;Shioya N et al.Mixed cultures comparising syngeneic and allogeneic mouse Keratinocytes as a graf table skin substitute[J].Transplantation,1995,59(09):1236. |
| [14] | Myers S R;Grady J;Soranzo C et al.A hyaluronic acid membrane delivery system for cultured keratinocytes:Clinical' take' rates in the porcine kerato-dermalmodel[J].Journal of Burn Care and Rehabilitation,1997,18(03):214. |
| [15] | Metcalfe A D;Ferguson M W .Tissue engineering of replacement skin:the crossroads of biomaterials,wound healing,embryonic development,stem cells and regeneration[J].J R Soc Interf,2007,4:413. |
| [16] | Kubo K;Kuroyanagi Y;et ai .Spongymatrix of hyaluronic acid and collagen as a cultured dermal substitute:Evaluation in the animal test[J].Artif Orgars,2003,6(01):64. |
| [17] | 刘强,柴家科,杨红明,尹会男.异种（猪）无细胞真皮基质与自体微粒皮复合移植修复深度烧伤创面的实验研究[J].中国危重病急救医学,2004(02):77-80. |
| [18] | 杨红明,柴家科,刘强,盛志勇.选择性脱细胞猪皮研制及早期临床应用[J].中国修复重建外科杂志,2004(05):423-425. |
| [19] | 梁黎明,柴家科,孙强,杨红明,陈敏亮,冯瑞.不同性状激光微孔脱细胞真皮构建活性基质的研究[J].中国美容医学,2008(01):66-68. |
| [20] | Chai JK;Liang LM;Yang HM;Feng R;Yin HN;Li FY;Sheng ZY .Preparation of laser micropore porcine acellular dermal matrix for skin graft: an experimental study.[J].Burns: Including Thermal Injury,2007(6):719-725. |
| [21] | Li-Ling Tang;Huan Liu;Yuan-Liang Wang;Cheng-Yu Xian;Ai-Hua Su .Evaluation of the biocompatibility of acellular porcine dermis[J].Colloids and Surfaces, B. Biointerfaces,2007(2):215-218. |
| [22] | 但卫华,廖隆理,林海,李志强,陈敏,王坤余,曾睿,但年华.3D-SC人工皮肤材料组织相容性的实验研究[J].生物医学工程与临床,2007(05):333-336,封3. |
| [23] | 王坤余,但卫华,李志强,陈敏,廖隆理,曾睿,但年华.3D-SC人工皮肤材料体外降解性能研究[J].中国修复重建外科杂志,2005(08):658-661. |
| [24] | 陈敏,廖隆理,但卫华,李志强,王坤余,曾睿,陈驰,但年华.3D-SC人工皮肤材料体内降解实验研究[J].生物医学工程与临床,2005(01):1-3. |
| [25] | 但卫华;廖隆理;李志强 等.脱细胞真皮基质材料的制备方法[P].中国,ZL200410022506.9,2005-01-26. |
| [26] | 关林波 .动物皮肤损伤修复方法的研究[D].成都:四川大学,2008. |
| [27] | Shanmugasundaram N;Ravichandran P;Reddy PN;Ramamurty N;Pal S;Rao KP .Collagen-chitosan polymeric scaffolds for the in vitro culture of human epidermoid carcinoma cells.[J].Biomaterials,2001(14):1943-1951. |
| [28] | Collier M .The use of advanced biological and tissue-engineered wound products.[J].Nursing standard,2006(7):68; 70; 72 passim-0. |
| [29] | Kawai K;Suzuki S;Tabata Y;Ikada Y;Nishimura Y .Accelerated tissue regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dermis.[J].Biomaterials,2000(5):489-499. |
| [30] | Macleod TM;Sarathchandra P;Williams G;Sanders R;Green CJ .The diamond CO(2) laser as a method of improving the vascularisation of a permanent collagen implant.[J].Burns: Including Thermal Injury,2004(7):704-712. |
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