简要介绍了丝素蛋白的特性以及丝素蛋白复合支架在医学组织工程中的应用,综述了丝素蛋白及其复合支架制备方法的研究进展,主要包括冷冻干燥法、静电纺丝法、气体发泡法、致孔剂制孔法、快速成型法等,同时还比较了各种制备方法的优缺点.
参考文献
| [1] | Meinel L;Fajardo R;Hofmann S et al.Silk implants for the healing of critical size bone defects[J].Bone,2005,37(05):688. |
| [2] | Uebersax L;Merkle HP;Meinel L .Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2008(1):12-21. |
| [3] | Liu H;Ge Z;Wang Y;Toh SL;Sutthikhum V;Goh JC .Modification of sericin-free silk fibers for ligament tissue engineering application.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2007(1):129-138. |
| [4] | Vieira A F K;Yu A;Kim C.In vivo silk fibroin biocompatibility[A].Fort Lauderdale,2010 |
| [5] | 李森,史晓远,林卫,范红松,陈宝,吴晖,胡旭栋,王光林.静电纺丝聚乳酸聚乙醇酸共聚物-丝素-胶原神经导管修复大鼠周围神经缺损[J].中国组织工程研究,2012(38):7087-7091. |
| [6] | Rockwood DN;Gil ES;Park SH;Kluge JA;Grayson W;Bhumiratana S;Rajkhowa R;Wang X;Kim SJ;Vunjak Novakovic G;Kaplan DL .Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study.[J].Acta biomaterialia,2011(1):144-151. |
| [7] | Nandana Bhardwaj;Subhas C Kundu .Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin/chitosan blends[J].Biomaterials,2012,33:2848. |
| [8] | Chen J P;Chen S H;Lai G J .Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture[J].Nanoscale Res Lett,2012,7(01):170. |
| [9] | Jetbumpenkul, P.;Amornsudthiwat, P.;Kanokpanont, S.;Damrongsakkul, S. .Balanced electrostatic blending approach - An alternative to chemical crosslinking of Thai silk fibroin/gelatin scaffold[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2012(1):7-13. |
| [10] | Jianglin Wang;Qin Yang;Chuanbin Mao;Shengmin Zhang .Osteogenic differentiation of bone marrow mesenchymal stem cells on the collagen/silk fibroin bi-template-induced biomimetic bone substitutes.[J].Journal of biomedical materials research, Part A,2012(11):2929-2938. |
| [11] | Zhu H L;Wu B W;Feng X X et al.Preparation and characterization of bioactive mesoporous calcium silicate-silk fibroin composite films[J].Journal of Biomedical Materials Research Part B:Applied Biomaterials,2011,98(02):330. |
| [12] | Liu L;Liu JY;Wang MQ;Min SJ;Cai YR;Zhu LJ;Yao JM .Preparation and characterization of nano-hydroxyapatite/silk fibroin porous scaffolds[J].Journal of biomaterials science,2008(3):325-338. |
| [13] | Jun S L;Chang S K;Jong W K et al.Fabrication and evaluation of poly (epsilon-caprolactone)/silk fibroin blend nanofibrous scaffold[J].Biopolymers(Peptide Science),2011,97(05):265. |
| [14] | Esther W;Anne J M;Sarah W et al.Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering[J].Biomaterials,2009,30:2571. |
| [15] | Guanqiang Zhou;Zhengzhong Shao;David P. Knight;Jiaping Yan;Xin Chen .Silk Fibers Extruded Artificially From Aqueous Solutions Of Regenerated Bombyx Mori Silk Fibroin Are Tougher Than Their Natural Counterparts[J].Advanced Materials,2009(3):366-370. |
| [16] | Kim HJ;Kim UJ;Kim HS;Li C;Wada M;Leisk GG;Kaplan DL .Bone tissue engineering with premineralized silk scaffolds.[J].Bone,2008(6):1226-1234. |
| [17] | Mandal BB;Kundu SC .Cell proliferation and migration in silk fibroin 3D scaffolds.[J].Biomaterials,2009(15):2956-2965. |
| [18] | 徐水,张胡静,张海萍,杨明英,朱良均.高强度力学性能丝素/羟基磷灰石多孔支架材料的初步制备[J].高分子材料科学与工程,2011(10):150-153. |
| [19] | Bhardwaj N;Chakraborty S;Kundu S C .Freeze-gelled silk fibroin protein scaffolds for potential applications in soft tissue engineering[J].International Journal of Biological Macromolecules,2011,49(03):260. |
| [20] | Kumiko Makaya;Shinichi Terada;Kosuke Ohgo .Comparative study of silk fibroin porous scaffolds derived from salt/water and sucrose/hexafluoroisopropanol in cartilage formation[J].Journal of Bioscience and Bioengineering,2009(1):68-75. |
| [21] | Li, Jinghui;Zhang, Lei;Lv, Shengyi;Li, Shengjie;Wang, Na;Zhang, Zhenting .Fabrication of individual scaffolds based on a patient-specific alveolar bone defect model[J].Journal of Biotechnology,2011(1):87-93. |
| [22] | Oragui E;Nannaparaju M;Khan W S .The role of bioreactors in tissue engineering for musculoskeletal applications[J].Open Orthop J,2011,5(z2):267. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%