铱催化 3-羟甲基-2H-苯并吡喃类化合物的不对称氢化

催化学报 , 2007, 28(10): 847-849.

1.中国科学院大连化学物理研究所,辽宁大连,116023

2.中国科学院大连化学物理研究所,辽宁大连,116023

基金项目: 国家自然科学基金(20672112)

Iridium-Catalyzed Asymmetric Hydrogenation of (2H-chromen-3-yl)methanols

从(1R,2S)-环己烷吡啶醇出发,合成了具有不同轴手性的反式环己烷骨架铱络合物,并将其应用于 3-羟甲基-2H-苯并吡喃的不对称氢化中. 结果表明,当以Ir-8为催化剂,二氯甲烷为溶剂,氢气压力 5 MPa, 室温反应16 h时,可以取得极好的反应活性,产物最高对映选择性可达94%.

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