研究了纯镁及表面改性纯镁样品植入动物骨组织后在镁-骨界面处的降解机制以及材料对周围骨组织的影响.选择纯系日本大耳白兔,于股骨处植入样品.术后1、5周后,取出样品制作半薄切片,进行光学显微镜、扫描电镜观察.研究发现,镁棒周围新生类骨组织沉积速度很快,说明镁的腐蚀降解并没有影响骨组织修复过程.结果表明,镁在降解期间安全性较高,有较好的组织相容性.
参考文献
| [1] | Niinomi M .[J].Metallurgical and Materials Transactions A:Physical Metallurgy and Materials Science,2002,33:477. |
| [2] | Puleo D A;Huh W W .[J].Journal of Applied Biomaterials,1995,6:109. |
| [3] | Jacobs J J;Gilbert J L;Urban R M .[J].Journal of BONE AND JOINT SURGERY-BRITISH VOLUME,1998,80:268. |
| [4] | Bi Y;van de Motter R R;Ragab A A et al.[J].Journal of Biomedical Materials Research,2001,83:501. |
| [5] | Huang Jingjing;Yang Ke .[J].Materials Review,2006,20:4. |
| [6] | 浦素云.金属植入材料及其腐蚀[M].北京:北京航空航天大学出版社,1990:29. |
| [7] | Mark P Staiger;Alexis M Pietak;Jerawala Huadmai et al.[J].Biomaterials,2006,27:1013. |
| [8] | 邵美珍.镁的基础与临床[M].成都:四川科学技术出版社,1996:3. |
| [9] | Ren Yibin;Huang Jingjing;Yang Ke .[J].Acta Metallurgica Sinica,2005,41:1228. |
| [10] | Wittea F;Kaeseb V;Haferkampb H .[J].Biomaterials,2005,26:3557. |
| [11] | Chen Jianzhi;Shi Yulong;Wang Lei et al.[J].Materials Letters,2006,60(20):2538. |
| [12] | 侯树勋.现代创伤骨科学[M].北京:人民军医出版社,2002:28. |
| [13] | Zreiqat H;Howlett C R;Zannettino A et al.[J].Journal of Biomedical Materials Research,2002,62:175. |
| [14] | Yamasaki Y;Yoshida Y;Okazaki M et al.[J].Journal of Biomedical Materials Research,2002,62:99. |
| [15] | Yamasaki Y;Yoshida Y;Okazaki M;Shimazu A;Kubo T;Akagawa Y;Uchida T .Action of FGMgCO(3)Ap-collagen composite in promoting bone formation.[J].Biomaterials,2003(27):4913-4920. |
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