Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine)

武汉理工大学学报-材料科学版(英文版), 2005, 20(z1): 294-296.

^1, , ^2, , ^3, , ^4, , ^5,

1.Shanghai Cancer Institute,Shanghai Jiaotong University,Shanghai 200032,China

2.Shanghai Cancer Institute,Shanghai Jiaotong University,Shanghai 200032,China

3.State Key Laboratory for Modification of Chemical Fibers and Polymer Material,Donghua University,Shanghai 200051,China

4.State Key Laboratory for Modification of Chemical Fibers and Polymer Material,Donghua University,Shanghai 200051,China

5.Shanghai Cancer Institute,Shanghai Jiaotong University,Shanghai 200032,China;State Key Laboratory for Modification of Chemical Fibers and Polymer Material,Donghua University,Shanghai 200051,China

基金项目: 上海市自然科学基金(04zr14008)

Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine)

Keywords： RGD

The poly ( lactic acid- co-lysine ) was synthesized using IR and 1 H NMR to characterize the copolymer. And then the RGD modification copolymer RGD-PLAL was prepared. The contact angles were used to see the RGD modification occurrence. Also high molecular weight polymer was controlled to the reaction of polymerization of copolymer.

参考文献

[1]	Quirk RA;Chan WC;Davies MC;Tendler SJ;Shakesheff KM .Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid).[J].Biomaterials,2001(8):865-872.
[2]	Denise A Barrera;Eric Zylstra;Langer R .Synthesis and RGD Peptide Modification of a New Biodegradable Copolymer:Poly (lactic acid-co-lysine)[J].Journal of the American Chemical Society,1993,115:11010-11011.
[3]	Hrkach J S;Ou J;Langer R .Synthsis of Poly(lactic acid-co-lysine) Copolymers[J].Macromolecules,1995,28:4736-4739.
[4]	Caponetti G;Hrkach JS;Kriwet B;Poh M;Lotan N;Colombo P;Langer R .Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization.[J].Journal of Pharmaceutical Sciences,1999(1):136-141.

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材料期刊网

Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine)

参考文献