环糊精改性聚乳酸(PLA-β-CD)是一种全生物降解的新型生物材料.考察了环糊精改性聚乳酸基生物材料的体外降解行为,包括材料在蒸馏水中的pH值变化和在pH=7.4 PBS中的失重率变化.结果表明,PLA-β-CD与PLA的降解行为相似,PLA-β-CD的分子主链没有被破坏,没有出现引入酸酐导致材料酸性进一步增强的现象.
参考文献
| [1] | Bostman O;Pihlajamaki H .Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review.[J].Biomaterials,2000(24):2615-2621. |
| [2] | Nouvel C;Raynaud J;Marie E;Dellacherie E;Six JL;Durand A .Biodegradable nanoparticles made from polylactide-grafted dextran copolymers[J].Journal of Colloid and Interface Science,2009(2):337-343. |
| [3] | Jin S.;Gonsalves KE. .Synthesis of poly(l-lactide-co-serine) and its graft copolymers with poly(ethylene glycol)[J].Polymer: The International Journal for the Science and Technology of Polymers,1998(21):5155-5162. |
| [4] | Quirk RA;Chan WC;Davies MC;Tendler SJ;Shakesheff KM .Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid).[J].Biomaterials,2001(8):865-872. |
| [5] | Suh JK;Matthew HW .Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review.[J].Biomaterials,2000(24):2589-2598. |
| [6] | Ferreira L;Gil MH;Cabrita AMS;Dordick JS .Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels[J].Biomaterials,2005(23):4707-4716. |
| [7] | Grainger D A;Meyer W R;Dechemey A H et al.The use of hyaluronic acid polymers to reduce postoperative adhesions[J].Journal of Gynecologic Surgery,1991,7(02):97. |
| [8] | 黄毅;黄金花;谢青季 et al.糖-蛋白质相互作用[J].化学进展,2003,20(06):943. |
| [9] | Gao H;Yang YW;Fan YG;Ma JB .Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(3):301-311. |
| [10] | 潘彤,张国林,马建标.β-环糊精/聚（DL-丙交酯）接枝共聚物的合成与表征[J].高分子学报,2006(02):330-334. |
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