通过纳米沉淀法制备了一种粒径均一的琼脂糖醋酸酯纳米粒子,并对影响粒径的相关因素进行了研究。结果表明,纳米粒子分别随着二甲基亚砜（DMSO）与水的比率、姜黄素含量及琼脂糖醋酸酯（AA）的浓度的增加而增大,随转速的增加而下降,异丙醇和聚乙烯醇（PVA）浓度也有一定的影响。同时研究了载体对姜黄素的包载情况及缓释行为。结果显示,无异丙醇组中姜黄素载药率和包封率均比异丙醇组中的高。但两组都表明,随着姜黄素的含量增加,载药粒子的载药率不断增加,包封率不断降低。载药粒子大大延长了姜黄素的缓释时间。获得的琼脂糖醋酸酯纳米粒子可望用于姜黄素的控释。
In this paper, the preparation of uniform agarose acetate nanoparticles （AA-NPs） by nanoprecipitation was investigated with the following conditions： （1） emulsifier PVA concentration, （2） co-emulsifier isopropanol, （3） AA concentration, （4） the ratio of dimethyl sulfoxide （DMSO） to water, （5） the stirring rate, and （6） drug content. The results show that the size of AA-NPs has a close relationship with conditions above. In addition, the drug loading capacity and in vitro drug release of the AA-C-NPs were investigated. The results show that the loading rate and encapsulation efficiency of AA-C-NPs without isopropanol are higher than that with isopropanol. But both of them show a tendency that the loading rate obviously increases but encapsulation efficiency decreases with increasing of initial curcumin concentration. The result of in vitro release shows a burst effect at the beginning stage, a slow and continuous release followed.
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